Evidence That Zika Virus Is Transmitted by Breastfeeding to Newborn A129 (Ifnar1 Knock-Out) Mice and Is Able to Infect and Cross a Tight Monolayer of Human Intestinal Epithelial Cells

Frontiers in Microbiology
Mathieu HubertAurore Vidy

Abstract

Zika virus (ZIKV) belongs to the Flavivirus genus in the Flaviviridae family. Mainly transmitted via mosquito bites (Aedes aegypti, Aedes albopictus), ZIKV has been classified in the large category of arthropod-borne viruses, or arboviruses. However, during the past two outbreaks in French Polynesia (2013-2014) and Latin America (2015-2016), several cases of ZIKV human-to-human transmission were reported, either vertically via transplacental route but also horizontally after sexual intercourse. Interestingly, high viral burdens were detected in the colostrum and breast milk of infected women and mother-to-child transmission of ZIKV during breastfeeding was recently highlighted. In a previous study, we highlighted the implication of the mammary epithelium (blood-milk barrier) in ZIKV infectious particles excretion in breast milk. However, mechanisms of their further transmissibility to the newborn via oral route through contaminated breast milk remain unknown. In this study, we provide the first experimental proof-of-concept of the existence of the breastfeeding as a route for mother-to-child transmission of ZIKV and characterized the neonatal oral transmission in a well-established mouse model of ZIKV infection. From a mechanis...Continue Reading

References

Aug 22, 1981·Lancet·D B Jelliffe, E F Jelliffe
Jun 1, 1997·FEMS Immunology and Medical Microbiology·K Numazaki
Dec 29, 2000·Annals of the New York Academy of Sciences·P Van de Perre
Aug 20, 2002·The Journal of General Virology·Laurent OuzilouFlorence Colbère-Garapin
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Sep 16, 2004·Journal of Virology·Robert F Ramig
Mar 3, 2007·Pediatrics·Alison F HinckleyEdward B Hayes
Jun 12, 2009·The New England Journal of Medicine·Mark R DuffyEdward B Hayes
Feb 18, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Susan KuhnBarbara Law
Apr 12, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anne BarthelElodie Descloux
Feb 11, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·S KutsunaN Ohmagari
May 27, 2014·Emerging Infectious Diseases·Van-Mai Cao-LormeauDidier Musso
Jun 10, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D MussoV-M Cao-Lormeau
Oct 9, 2014·The American Journal of Tropical Medicine and Hygiene·Kevin FonsecaRaymond Tellier
Dec 23, 2014·Emerging Infectious Diseases·Ann-Claire GourinatMyrielle Dupont-Rouzeyrol
Jan 15, 2015·Journal of Laboratory Automation·Balaji SrinivasanJames J Hickman
Jan 28, 2015·Emerging Infectious Diseases·Didier MussoVan-Mai Cao-Lormeau
Feb 11, 2016·The New England Journal of Medicine·Jernej MlakarTatjana Avšič Županc
Feb 28, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Renata de M CamposDavis F Ferreira
Mar 6, 2016·Lancet·Myrielle Dupont-RouzeyrolElodie Descloux
Mar 8, 2016·The Lancet Infectious Diseases·Jean Michel MansuyGuillaume Martin-Blondel
Mar 19, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Luisa BarzonGiorgio Palù
Mar 31, 2016·The New England Journal of Medicine·Rita W DriggersOlli Vapalahti
Apr 1, 2016·Clinical Microbiology Reviews·Didier Musso, Duane J Gubler
Apr 14, 2016·The New England Journal of Medicine·Eric D'OrtenzioIsabelle Leparc-Goffart
Apr 14, 2016·The New England Journal of Medicine·Sonja A RasmussenLyle R Petersen
May 24, 2016·Cell Host & Microbe·Alesha GrantAdolfo García-Sastre
Jun 30, 2016·Lancet·Vivian I Avelino-Silva, Jeffrey N Martin
Jul 19, 2016·Travel Medicine and Infectious Disease·Franca GrischottPatricia Schlagenhauf
Sep 28, 2016·The Lancet Infectious Diseases·Jean Michel MansuyGuillaume Martin-Blondel
Oct 18, 2016·Emerging Infectious Diseases·Kristy O MurrayMark J Mulligan
Oct 21, 2016·Journal of the Pediatric Infectious Diseases Society·Lucille ArragainElodie Descloux
Oct 21, 2016·Archives of Pathology & Laboratory Medicine·David A Schwartz
Nov 28, 2016·Virus Research·Stephanie PfaenderVolker Thiel
Jan 28, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Pauline PenotJean-Michel Molina
Feb 6, 2017·Journal of Virology·Thomas E Morrison, Michael S Diamond
Feb 12, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Marta G CavalcantiJosé M Peralta
Feb 14, 2017·Emerging Infectious Diseases·José R SoteloCristovao L P Mangueira
Apr 30, 2017·Genome Announcements·Gabriela M BlohmAlberto E Paniz-Mondolfi
Jun 20, 2017·Emerging Infectious Diseases·Tania AyllónNildimar Alves Honório

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Datasets Mentioned

BETA
KX369547
KU991811

Methods Mentioned

BETA
Assay
flow cytometry
fluorescence activating cell sorting
PCR
transmission electron microscopy

Software Mentioned

FlowJo
Prism
EC

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