Evidences for prevention of nitroglycerin tolerance by carvedilol

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Ebtehal El-Demerdash

Abstract

Carvedilol, a beta-blocker has shown clinically to attenuate the development of nitroglycerin (NTG) tolerance. The present study was designed to investigate the possible mechanisms whereby carvedilol could prevent NTG tolerance, particularly at the level of vascular superoxide anion (O2-) production (an important factor in nitrate tolerance) as well as modulation of certain aortic antioxidants. Rabbits were treated with NTG patch (1.5 microg/kg/min) and/or cavedilol (10 mg/kg/day) for 3 days. Relaxation of aortic segments was studied in organ chamber and rate of vascular O2- production was determined. In addition, aortic glutathione (GSH) level and superoxide dismutase (SOD) activity was also assessed. Aortic segments from NTG-treated rabbits showed a significant decrease in maximal relaxation in response to various vasodilators. Also, NTG treatment increased vascular O2- production by two-fold as compared with untreated control group. The potential source of O2- production was found to be the adventitia. In addition, treatment of rabbits with NTG induced a significant decrease in total GSH level and SOD activity by 46 and 53%, respectively, as compared with the control values. Concomitant treatment of NTG with carvedilol signi...Continue Reading

Citations

Jun 12, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Li HeYexin Ma
Sep 14, 2014·Heart Failure Clinics·Robert T ColeJaved Butler
Jun 25, 2008·British Journal of Pharmacology·B Mayer, M Beretta
Mar 14, 2014·JACC. Heart Failure·Divya GuptaJaved Butler

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