Evidences for the mechanism of Shenmai injection antagonizing doxorubicin-induced cardiotoxicity.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
You-Ping WuZhen-Qiang You

Abstract

Doxorubicin (DOX) is a widely used antitumor drug. However, its clinical application is limited for its serious cardiotoxicity. The mechanism of DOX-induced cardiotoxicity is attributed to the increasing of cell stress in cardiomyocytes, then following autophagic and apoptotic responses. Our previous studies have demonstrated the protective effect of Shenmai injection (SMI) on DOX-induced cardiotoxicity via regulation of inflammatory mediators for releasing cell stress. To further investigate whether SMI attenuates the DOX-induced cell stress in cardiomyocytes, we explored the mechanism underlying cell stress as related to Jun N-terminal kinase (JNK) activity and the regulation of autophagic flux to determine the mechanism by which SMI antagonizes DOX-induced cardiotoxicity. The DOX-induced cardiotoxicity model of autophagic cell death was established in vitro to disclose the protected effects of SMI on oxidative stress, autophagic flux and JNK signaling pathway. Then the autophagic mechanism of SMI antagonizing DOX cardiotoxicity was validated in vivo. SMI was able to reduce the DOX-induced cardiomyocyte apoptosis associated with inhibition of activation of the JNK pathway and the accumulation of reactive oxygen species (ROS)....Continue Reading

References

Jun 26, 2002·Kidney International·Hirohiko TsuganezawaRobert J Alpern
Jun 24, 2008·Molecular Cell·Yongjie WeiBeth Levine
Apr 10, 2009·European Journal of Pharmacology·Hong XinYi Zhun Zhu
Mar 13, 2010·The Journal of Pathology·Danielle GlickKay F Macleod
Apr 3, 2012·Journal of Molecular and Cellular Cardiology·Yanti OctaviaAn L Moens
Oct 31, 2012·Autophagy·Monika Kijanska, Matthias Peter
Mar 16, 2013·Medicinal Research Reviews·Filipa S CarvalhoPaulo J Oliveira
Oct 22, 2013·Nature Medicine·Yasuhiro MaejimaJunichi Sadoshima
Jan 3, 2014·The Journal of Clinical Investigation·Yoshihiko IchikawaHossein Ardehali
Mar 26, 2014·Nature Reviews. Endocrinology·Kook Hwan Kim, Myung-Shik Lee
Jan 13, 2015·Journal of Cancer Research and Therapeutics·Sangeeta Rivankar
Mar 24, 2015·Physiological Measurement·T Lončar-TurukaloN Japunžić-Žigon
Dec 3, 2015·Cold Spring Harbor Perspectives in Biology·Douglas R Green, Fabien Llambi
Dec 13, 2016·Free Radical Biology & Medicine·Ye Yan, Toren Finkel
Feb 22, 2017·Free Radical Biology & Medicine·Jaakko L Pohjoismäki, Steffi Goffart
Jun 1, 2017·The Journal of Pharmacology and Experimental Therapeutics·Emanuela SalvatorelliGiorgio Minotti
Aug 10, 2018·Journal of Pineal Research·Lucas Sagrillo-FagundesCathy Vaillancourt
Nov 21, 2019·BMC Complementary and Alternative Medicine·Sheng ZhangYan-Fei Xin

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