Aug 12, 2016

Evo-engineering and the Cellular and Molecular Origins of the Vertebrate Spinal Cord

BioRxiv : the Preprint Server for Biology
Benjamin Steventon, Alfonso Martinez Arias


The formation of the spinal cord during early embryonic development in vertebrate embryos is a continuous process that begins at gastrulation and continues through to the completion of somitogenesis. Despite the conserved usage of patterning mechanisms and gene regulatory networks that act to generate specify spinal cord progenitors, there now exists two seemingly disparate models to account for their action. In the first, a posterior localized signalling source transforms previously anterior-specified neural plate into the spinal cord. In the second, a population of bipotent stem cells undergo continuous self-renewal and differentiation to progressively lay down the spinal cord and axial mesoderm by posterior growth. Whether this represents fundamental differences between the experimental model organisms utilised in the generation of these models remains to be addressed. Here we review lineage studies across four key vertebrate models: mouse, chicken, Xenopus and zebrafish and relate this to the underlying gene regulatory networks that are known to be required for spinal cord formation. We propose that by applying a dynamical systems approach to understanding how distinct neural and mesodermal fates arise from a bipotent proge...Continue Reading

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Mentioned in this Paper

Cell Movement
Cell Motility
Malignant Neoplasm of Spinal Cord
Neoplasm of Uncertain or Unknown Behavior of Spinal Cord
Embryonic Development
Cell Proliferation
Cell Differentiation Process

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