Evoked potential changes in patients with Parkinson's disease

Brain and Behavior
Chunyan LiuSongbin He

Abstract

Patients with Parkinson's disease (PD) may have sensory dysfunction, and it can be more easily demonstrated through electrophysiologic testing. We aimed to explore whether the impairment of brainstem visual and auditory passageway exists in PD patients using visual evoked potential (VEP) and brainstem auditory evoked potential (BAEP) examinations. Forty-two PD cases and thirty controls participated in the study. All subjects underwent the VEP and BAEP examinations. The N75, P100, N145 latencies and P100 amplitude of VEP, the latencies of waves I, III, V and the interpeak latencies (IPL) of waves I-III, III-V, I-V were measured. The N75, P100, N145 latencies of VEP, but not the amplitude of P100, were significantly longer in patients with PD than the control group (p < .05). The latencies of wave III and wave V, the IPL of III-V and I-V were all significantly increased compared with control subjects while no significant difference was noted in waves I and I-III IPL. Our results found that brainstem visual and auditory passageway may be impaired in PD patients. VEP and BAEP can be served as sensitive measurements in helping prognosis and assessment the severity of the disease.

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Citations

Feb 14, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Zahra JafariMajid H Mohajerani
Aug 9, 2020·Frontiers in Neurology·Evelien De GrooteMiet De Letter
Nov 17, 2020·Frontiers in Neuroscience·Alessia IndrieriElvira De Leonibus
Apr 26, 2021·Journal of Neural Transmission·Evelien De GrooteMiet De Letter
Jun 3, 2021·Brain Sciences·Diana Sipos-LascuLăcrămioara Perju-Dumbravă
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Siyu LiXia Gao

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