Evoking visual neglect-like deficits in healthy volunteers - an investigation by repetitive navigated transcranial magnetic stimulation

Brain Imaging and Behavior
Katrin GiglhuberSandro M Krieg

Abstract

In clinical practice, repetitive navigated transcranial magnetic stimulation (rTMS) is of particular interest for non-invasive mapping of cortical language areas. Yet, rTMS studies try to detect further cortical functions. Damage to the underlying network of visuospatial attention function can result in visual neglect-a severe neurological deficit and influencing factor for a significantly reduced functional outcome. This investigation aims to evaluate the use of rTMS for evoking visual neglect in healthy volunteers and the potential of specifically locating cortical areas that can be assigned for the function of visuospatial attention. Ten healthy, right-handed subjects underwent rTMS visual neglect mapping. Repetitive trains of 5 Hz and 10 pulses were applied to 52 pre-defined cortical spots on each hemisphere; each cortical spot was stimulated 10 times. Visuospatial attention was tested time-locked to rTMS pulses by a landmark task. Task pictures were displayed tachistoscopically for 50 ms. The subjects' performance was analyzed by video, and errors were referenced to cortical spots. We observed visual neglect-like deficits during the stimulation of both hemispheres. Errors were categorized into leftward, rightward, and no r...Continue Reading

References

Feb 1, 1995·Brain and Cognition·M HarveyR C Roberts
Mar 8, 2000·Acta Neurologica Scandinavica·M JehkonenG Molnár
May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Dec 14, 2004·Human Brain Mapping·David P CorinaGeorge A Ojemann
Oct 20, 2005·Nature Neuroscience·Maurizio CorbettaAyelet Sapir
Dec 7, 2006·Behavioural Neurology·Brigida FierroEdoardo Bisiach
Oct 17, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simone RossiUNKNOWN Safety of TMS Consensus Group
Mar 17, 2010·Neurophysiologie clinique = Clinical neurophysiology·J Ruohonen, J Karhu
Aug 18, 2010·Restorative Neurology and Neuroscience·Alexander T Sack
Jun 23, 2011·Annual Review of Neuroscience·Maurizio Corbetta, Gordon L Shulman
Jul 16, 2011·Neuropsychologia·Hans-Otto Karnath, Christopher Rorden
Nov 10, 2011·Neurosurgery·Franck-Emmanuel RouxJean-François Démonet
Nov 24, 2011·Journal of Neuroscience Methods·Pantelis LioumisJyrki P Mäkelä
Dec 6, 2011·Neurocase·Jay Cheol KwonKenneth M Heilman
Jan 11, 2012·Neuropsychologia·Julia SuchanHans-Otto Karnath
Mar 27, 2012·Journal of Neurosurgery·Nader SanaiMitchel S Berger
May 23, 2012·Neuropsychologia·Bianca de HaanJon Driver
Jul 24, 2012·Frontiers in Human Neuroscience·Mario Bonato
Jan 4, 2013·Human Brain Mapping·Julia SuchanDorothee Saur
Mar 16, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Woo Jin KimNam-Jong Paik
May 25, 2013·NeuroImage·Phiroz E TaraporeSrikantan S Nagarajan
Oct 12, 2013·Handbook of Clinical Neurology·Pedro Cavaleiro Miranda
Sep 3, 2014·Neuropsychology·Daniela L SacchettiA M Barrett
Jan 23, 2015·Brain : a Journal of Neurology·Marine LunvenPaolo Bartolomeo

❮ Previous
Next ❯

Software Mentioned

Nexstim eXimia System
NEXSPEECH
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.