Jan 21, 2014

Evolution and classification of myosins, a paneukaryotic whole-genome approach

Genome Biology and Evolution
Arnau Sebé-PedrósIñaki Ruiz-Trillo

Abstract

Myosins are key components of the eukaryotic cytoskeleton, providing motility for a broad diversity of cargoes. Therefore, understanding the origin and evolutionary history of myosin classes is crucial to address the evolution of eukaryote cell biology. Here, we revise the classification of myosins using an updated taxon sampling that includes newly or recently sequenced genomes and transcriptomes from key taxa. We performed a survey of eukaryotic genomes and phylogenetic analyses of the myosin gene family, reconstructing the myosin toolkit at different key nodes in the eukaryotic tree of life. We also identified the phylogenetic distribution of myosin diversity in terms of number of genes, associated protein domains and number of classes in each taxa. Our analyses show that new classes (i.e., paralogs) and domain architectures were continuously generated throughout eukaryote evolution, with a significant expansion of myosin abundance and domain architectural diversity at the stem of Holozoa, predating the origin of animal multicellularity. Indeed, single-celled holozoans have the most complex myosin complement among eukaryotes, with paralogs of most myosins previously considered animal specific. We recover a dynamic evolutiona...Continue Reading

  • References81
  • Citations34

References

  • References81
  • Citations34

Citations

Mentioned in this Paper

Myosin III
Genome
Cell Motility
Tertiary Protein Structure
Motility
Phylogeny
Genomics
Protein Domain
Actomyosin Adenosinetriphosphatase
Fungi

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