PMID: 8996341Feb 1, 1997Paper

Evolution and clinical significance of the T cell proliferative and cytokine response directed against the fibronectin binding antigen 85 complex of bacillus Calmette-Guerin during intravesical treatment of superficial bladder cancer

The Journal of Urology
A R ZlottaK Huygen

Abstract

The antitumorigenic effect of intravesical bacillus Calmette-Guerin (BCG) in superficial bladder cancer was reported to be initiated by the attachment of BCG to the bladder wall via fibronectin. The antigen 85 complex secreted in BCG culture filtrate binds specifically to fibronectin and is a powerful T cell stimulus. Therefore, we investigated the evolution and clinical significance of the cellular proliferative response and cytokine production during intravesical BCG therapy against this purified antigen 85 complex. Evolution of the lymphoproliferation, interleukin-2 and interferon-gamma production of peripheral blood lymphocytes against tuberculin (purified protein derivative), purified antigen 85, BCG culture filtrate, whole BCG bacilli and pokeweed mitogen was tested before and after 6 weekly intravesical BCG instillations in 29 patients with superficial bladder cancer at intermediate or high risk for recurrence. A major increase in the lymphoproliferative response against purified protein derivative, antigen 85, BCG culture filtrate, whole BCG and pokeweed mitogen was observed in 69.0, 65.5, 79.3, 48.3 and 65.3% of the patients, respectively, analyzed after BCG therapy. Reactivity returned to baseline values at 6 months o...Continue Reading

References

Nov 4, 1994·Science·S W LoweT Jacks
Aug 1, 1993·Current Opinion in Immunology·I M Orme

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Citations

Jun 12, 2004·Postgraduate Medical Journal·T R L Griffiths, J K Mellon
Oct 26, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y H GanK Esuvaranathan
Mar 16, 2011·BJU International·John M FitzpatrickAlexandre Zlotta
Aug 24, 2000·International Journal of Cancer. Journal International Du Cancer·A R ZlottaK Huygen
Sep 2, 1998·British Journal of Urology·N A Mungan, J A Witjes
Jan 15, 1999·British Journal of Cancer·M C FilionN C Phillips

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