Evolution and Comparative Genomics of F33:A-:B- Plasmids Carrying blaCTX-M-55 or blaCTX-M-65 in Escherichia coli and Klebsiella pneumoniae Isolated from Animals, Food Products, and Humans in China

MSphere
Jing WangJian-Hua Liu

Abstract

To understand the underlying evolution process of F33:A-:B- plasmids among Enterobacteriaceae isolates of various origins in China, the complete sequences of 17 blaCTX-M-harboring F33:A-:B- plasmids obtained from Escherichia coli and Klebsiella pneumoniae isolates from different sources (animals, animal-derived food, and human clinics) in China were determined. F33:A-:B- plasmids shared similar plasmid backbones comprising replication, leading, and conjugative transfer regions and differed by the numbers of repeats in yddA and traD and by the presence of group II intron, except that pHNAH9 lacked a large segment of the leading and transfer regions. The variable regions of F33:A-B- plasmids were distinct and were inserted downstream of the addiction system pemI/pemK, identified as the integration hot spot among F33:A-B- plasmids. The variable region contained resistance genes and mobile elements or contained segments from other types of plasmids, such as IncI1, IncN1, and IncX1. Three plasmids encoding CTX-M-65 were very similar to our previously described pHN7A8 plasmid. Four CTX-M-55-producing plasmids contained multidrug resistance regions related to that of F2:A-B- plasmid pHK23a from Hong Kong. Five plasmids with IncN and/o...Continue Reading

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Citations

Apr 4, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Huiyun ZouLennart E Nilsson
Jul 31, 2019·The Journal of Antimicrobial Chemotherapy·Dandan HeGongzheng Hu
Jun 25, 2019·Frontiers in Microbiology·Chuan-Zhen ZhangHong-Xia Jiang
Mar 31, 2020·The Lancet Infectious Diseases·Ying HuangJian-Hua Liu
Oct 7, 2021·Microbiology Spectrum·Yushan PanDandan He

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Datasets Mentioned

BETA
JQ432559
CP022157

Methods Mentioned

BETA
PCR
electrophoresis
454 GS

Software Mentioned

SOAPdenovo
454 GS
Newbler
RAST

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