Evolution and dispersal of St. Louis encephalitis virus in the Americas

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Albert J AugusteChristine V F Carrington

Abstract

Using a Bayesian coalescent approach on a dataset of 73 envelope gene sequences we estimated substitution rates and dates of divergence for St. Louis encephalitis virus (SLEV) in the Americas. We found significant rate heterogeneity among lineages, such that "relaxed" molecular clock models were much better supported than a strict molecular clock. The mean substitution rate estimated for all SLEV was 4.1x10(-4)substitutions/site/year (95% HPD 2.5-5.7)-higher than previous estimates that relied on the less well-suited strict clock. Mean substitution rates for individual lineages varied from 3.7x10(-4) to 7.2x10(-4)substitutions/site/year. For the first time we also assessed the magnitude and direction of viral gene flow within the Americas. The overall direction of gene flow during the period represented by the phylogeny is from South to North, and the region between 15 degrees N and 30 degrees N latitude appears to be the major source of virus for the rest of North America, which is consistent with migratory birds returning to their northern breeding grounds having acquired infection while wintering in the region of the Gulf of Mexico.

Citations

Jul 22, 2010·Vector Borne and Zoonotic Diseases·Ana Carolina Bernardes TerzianMaurício Lacerda Nogueira
Jun 14, 2013·MBio·Anne KoppSandra Junglen
Feb 4, 2012·PLoS Neglected Tropical Diseases·Luis Adrian DíazMarta Silvia Contigiani
Nov 28, 2013·PLoS Neglected Tropical Diseases·Roberta RosaRenato Lima Santos
Apr 5, 2013·Evolution; International Journal of Organic Evolution·Jennifer Hoyal Cuthill, Michael A Charleston
Jun 23, 2010·Journal of Viral Hepatitis·B E PickettE J Lefkowitz
Jul 2, 2010·The Journal of General Virology·Sueli G RodriguesPedro F C Vasconcelos
May 23, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Laura E ValinottoAlicia S Mistchenko
Mar 6, 2015·Archives of Virology·Danila VedovelloMaurício Lacerda Nogueira
Aug 28, 2015·Memórias do Instituto Oswaldo Cruz·Richard Hoyos-LópezJuan Carlos Gallego-Gómez
Oct 30, 2015·Journal of Virology·Francesca Di GiallonardoEdward C Holmes
Jun 11, 2020·PLoS Neglected Tropical Diseases·Daniele M SwetnamLark L Coffey
Dec 13, 2019·PloS One·Fábio Alves GomesLuiz Tadeu Moraes Figueiredo
Mar 5, 2021·Biological Reviews of the Cambridge Philosophical Society·Robert Poulin, Daniela de Angeli Dutra
Oct 26, 2021·Food and Environmental Virology·Bibhudutta Mishra, Raviprasad Aduri

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