Evolution and function of the TCR Vgamma9 chain repertoire: It's good to be public

Cellular Immunology
C David Pauza, Cristiana Cairo

Abstract

Lymphocytes expressing a T cell receptor (TCR) composed of Vgamma9 and Vdelta2 chains represent a minor fraction of human thymocytes. Extrathymic selection throughout post-natal life causes the proportion of cells with a Vgamma9-JP rearrangement to increase and elevates the capacity for responding to non-peptidic phosphoantigens. Extrathymic selection is so powerful that phosphoantigen-reactive cells comprise about 1 in 40 circulating memory T cells in healthy adults and the subset expands rapidly upon infection or in response to malignancy. Skewing of the gamma delta TCR repertoire is accompanied by selection for public gamma chain sequences such that many unrelated individuals overlap extensive in their circulating repertoire. This type of selection implies the presence of a monomorphic antigen-presenting molecule that is an object of current research but remains incompletely defined. While selection on a monomorphic presenting molecule may seem unusual, similar mechanisms shape the alpha beta T cell repertoire including the extreme examples of NKT or mucosal-associated invariant T cells (MAIT) and the less dramatic amplification of public Vbeta chain rearrangements driven by individual MHC molecules and associated with resis...Continue Reading

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K W WucherpfennigD A Hafler
Sep 1, 1991·The Journal of Experimental Medicine·K UyemuraR L Modlin
May 1, 1990·The Journal of Experimental Medicine·C M ParkerM B Brenner
Nov 1, 1989·The Journal of Experimental Medicine·G CasoratiN Migone
Oct 1, 1988·The Journal of Experimental Medicine·A OkadaF W Alt
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K MaedaS Tonegawa
Mar 7, 1985·Nature·D H RauletS Tonegawa
Jul 10, 1986·Nature·M B BrennerM S Krangel
Feb 6, 1985·Nature·D M KranzS Tonegawa
Oct 1, 1984·Immunological Reviews·M M DavisS M Hedrick
Jan 1, 1993·The Journal of Clinical Investigation·H KohsakaD A Carson
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y TanakaC T Morita
Jul 19, 2001·Nature·T J AllisonD N Garboczi
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Máire F QuigleyDavid A Price

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Citations

May 4, 2018·Nature Communications·Martin S DaveyBenjamin E Willcox
Dec 17, 2015·American Journal of Reproductive Immunology : AJRI·Natasa StrboMargaret A Fischl
Apr 1, 2020·Cells·Alina Suzann FichtnerImmo Prinz
Mar 23, 2017·Nature Immunology·Bruno Silva-Santos, Jessica Strid
Jun 6, 2018·Frontiers in Immunology·Neil E McCarthy, Matthias Eberl
Jul 13, 2018·Frontiers in Immunology·Jonathan Fisher, John Anderson
Nov 26, 2019·The Journal of Clinical Investigation·Paul OgongoSamuel M Behar
Jul 18, 2018·Frontiers in Immunology·Carrie R WillcoxBenjamin E Willcox
Jun 26, 2018·Frontiers in Immunology·C David PauzaHaishan Li
Sep 29, 2019·Clinical & Translational Immunology·Sneha SantKatherine Kedzierska
Jun 9, 2020·Frontiers in Cellular and Infection Microbiology·Jennifer A Juno, Stephen J Kent
May 5, 2018·Frontiers in Immunology·Timm HoeresMartin Wilhelm
Aug 16, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria PapadopoulouDavid Vermijlen
Mar 7, 2020·Proceedings of the National Academy of Sciences of the United States of America·Alina S FichtnerThomas Herrmann
Jan 24, 2018·Cancer Immunology Research·Neidy V RodriguesSérgio Dias
Jul 27, 2018·Developmental and Comparative Immunology·Payal Damani-YokotaCynthia L Baldwin
Aug 28, 2021·Nature Reviews. Nephrology·Hannah KaminskiMatthias Eberl

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