Evolution and single-nucleotide polymorphisms in methicillin-resistant Staphylococcus aureus strains with reduced susceptibility to vancomycin and daptomycin, based on determination of the complete genome

Antimicrobial Agents and Chemotherapy
Tetsuo YamaguchiTetsuya Matsumoto

Abstract

We obtained a series of methicillin-resistant Staphylococcus aureus isolates, including both daptomycin-susceptible strain TD1 and daptomycin-resistant strain TD4, from a patient. We determined the complete genome sequences of TD1 and TD4 using next-generation sequencing, and only four single-nucleotide polymorphisms (SNPs) were identified, one each in capB (E58K), rpoB (H481Y), lytN (I16V), and mprF (V351E). We determined that these four SNPs were sufficient to cause the strains to develop daptomycin, vancomycin, and rifampin resistance.

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Citations

Jun 9, 2017·The Journal of Antimicrobial Chemotherapy·Jin Yang BaekJae-Hoon Song
Dec 12, 2017·PLoS Neglected Tropical Diseases·Cedar L MitchellDawn N Birdsell
Jun 22, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Gi Yong LeeSoo-Jin Yang
Sep 23, 2020·Antimicrobial Agents and Chemotherapy·Itaru NakamuraHidehiro Watanabe
Apr 23, 2020·Enfermedades infecciosas y microbiología clínica·Alejandra AsenjoJuan-Ignacio Alós
Jun 6, 2021·Enfermedades Infecciosas Y Microbiologia Clinica·Alejandra AsenjoJuan-Ignacio Alós

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