PMID: 22572384May 11, 2012Paper

Evolution and virulence of Panton-Valentine leukocidin-positive ST30 methicillin-resistant Staphylococcus aureus in the past 30 years in Japan

Biomedical Research
Hirokazu IsobeTatsuo Yamamoto

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) includes hospital-acquired MRSA (HAMRSA) and community-acquired MRSA (CA-MRSA). Panton-Valentine leukocidin (PVL)-positive multilocus sequence type 30 (ST30) MRSA is one of worldwide CA-MRSA, which has also persisted in Japan since the 1980s. However, unexpectedly, it was not the same ST30 clone throughout. Before 2000, it was HA-MRSA with spa43 and ψSa3sea (phage Sa3 carrying the sea gene) and only one PVL-positive MRSA in Japan; in the 1980s, ST30 MRSA accounted for 23.5% of HA-MRSA, showed multidrug resistance, had high MICs for oxacillin and imipenem, and caused decubitus and pneumonia in hospitalized patients. A dynamic clonal change (spa43/ψSa3sea→ spa19) occurred around 2000-2002. A rare spa43/ψSa3sea/SCCmecI-IE25923 genotype also emerged. After 2002, the prevalent spa19 clone was CA-MRSA; it accounted for only 0.3% (or less) of MRSA in hospitals but 7.6% of CA-MRSA. Since 2007, PVL-positive CA-MRSA with other ST types (such as ST8, ST22, and ST59) also emerged in Japan, albeit at a low frequency. ST30/spa19 CA-MRSA occasionally caused severe invasive infections and a novel ST1335/spa19 genotype emerged. These ST30/spa19 CA-MRSA and variants were identified by pulsed fie...Continue Reading

References

May 1, 1977·The Journal of Infectious Diseases·K ShimadaM Yamashiro
Feb 1, 1995·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·T Inamatsu
May 1, 1993·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·N SatoH Sasaki
Mar 26, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Teruyo ItoKeiichi Hiramatsu
Apr 28, 2005·The Lancet Infectious Diseases·Nicola ZetolaWilliam R Bishai
Aug 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tristan FerryJerome Etienne
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James H Jorgensen, Janet F Hindler
Apr 19, 2007·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·T BaranovichT Yamamoto
Oct 18, 2007·JAMA : the Journal of the American Medical Association·R Monina KlevensUNKNOWN Active Bacterial Core surveillance (ABCs) MRSA Investigators
Nov 10, 2007·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·S EnanyT Yamamoto
Jul 1, 2008·Trends in Microbiology·Binh An Diep, Michael Otto
Mar 13, 2009·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tomomi TakanoTatsuo Yamamoto
Sep 2, 2009·Antimicrobial Agents and Chemotherapy·UNKNOWN International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC)
Mar 23, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Wataru HiguchiTatsuo Yamamoto
Mar 26, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tatsuo YamamotoDa Shi
Nov 19, 2011·The International Journal of Artificial Organs·Lucio MontanaroCarla Renata Arciola
Dec 2, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yasuhisa IwaoTatsuo Yamamoto
Dec 14, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tatsuo YamamotoAkihito Nishiyama

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Citations

Jul 6, 2013·The Lancet Infectious Diseases·Yu-Yu Chuang, Yhu-Chering Huang
Jun 21, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yuki UeharaKeiichi Hiramatsu
Jun 4, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C-J Chen, Y-C Huang
Sep 21, 2016·Expert Review of Anti-infective Therapy·Kyungmin Huh, Doo Ryeon Chung

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