Evolution in clinical presentation of inflammatory bowel disease over time at diagnosis: a multicenter cohort study

European Journal of Gastroenterology & Hepatology
Stéphane NahonVered Abitbol

Abstract

Delayed diagnosis of inflammatory bowel disease (IBD) has become a major issue, particularly in terms of the presence of nonspecific and heterogeneous clinical signs. This study aimed to identify changes over time in the epidemiological characteristics and clinical presentation of IBD in a French cohort. Sociodemographic data from patients at three French hospitals (age, sex, country of origin, smoking habits) and characteristics of IBD [diagnostic delay, phenotype, location, first symptoms, first test suggesting diagnosis (endoscopy, imaging examination)] were collected in a computerized database (Focus_MICI). Four diagnostic time periods were assessed: <2000, 2000-2004, 2005-2009, and >2009. Among the 926 patients analyzed, 638 (<2000, n=181; 2000-2004, n=104; 2005-2009, n=147; >2009, n=206) had Crohn's disease (CD) and 288 (<2000, n=54; 2000-2004, n=39; 2005-2009, n=80; >2009, n=115) had ulcerative colitis (UC). For CD, statistically significant differences over time were observed for (a) the first revealing disease symptom [more frequent abdominal pain vs. chronic diarrhea (P<0.001)], (b) first investigation suggestive of diagnosis [more frequent computed tomography vs. colonoscopy (P<0.001)], and (c) CD behavior [more freq...Continue Reading

References

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Citations

Nov 15, 2019·Inflammatory Bowel Diseases·Tawnya M HansenLaura E Targownik
Jan 15, 2020·Gastroenterology Research and Practice·Evelyn Sayuri S ChinemAna Teresa P Carvalho
Mar 18, 2021·World Journal of Gastroenterology : WJG·Katia Farias E SilvaHeitor Siffert Pereira de Souza

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