Evolution in Europe of African swine fever genotype II viruses from highly to moderately virulent

Veterinary Microbiology
Gallardo CArias M

Abstract

Since its arrival in the Caucasus and Russia in 2007, African swine fever virus (ASFV) has spread widely and has now affected the EU countries of Estonia, Latvia, Lithuania, Poland and, more recently, the Czech Republic and Romania. The ever-increasing evidence of seropositive wild boar in certain areas suggests that some animals may be surviving for some time or could even be recovering from the disease. This could be due to acquired immunity after the primary infection and/or the presence of related viruses of reduced virulence. To assess these hypotheses, two ASFV field strains from Estonia were studied in vivo in two groups of domestic pigs. After an incubation period of 4 ± 1.6 days, the pigs inoculated intramuscularly with Es15/WB-Tartu 14 ASFV (group 2) developed clinical signs associated with acute disease and succumbed 7 and 11 days post infection (dpi). Pigs inoculated with Es15/WB-Valga-14 ASFV (group 1) had longer incubation times (8 days) than those in group 2 and developed variable clinical signs and lesions compatible with subacute and chronic forms of ASF; they succumbed at 11 and 25 dpi. The in-contact pigs in both groups became infected 7-14 days after exposure and exhibited variable clinical manifestations an...Continue Reading

Citations

Sep 25, 2017·Transboundary and Emerging Diseases·M AriasJ M Sánchez-Vizcaíno
Mar 23, 2019·Emerging Microbes & Infections·Dongming ZhaoZhigao Bu
Sep 20, 2019·Viruses·Katja SchulzCarola Sauter-Louis
Nov 20, 2019·Annual Review of Animal Biosciences·Linda K DixonDirk U Pfeiffer
May 7, 2020·Transboundary and Emerging Diseases·Edvīns OļševskisCarola Sauter-Louis
May 21, 2019·Frontiers in Veterinary Science·Jose A BarasonaJose M Sánchez-Vizcaíno
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Jun 9, 2020·Frontiers in Veterinary Science·Francisco J Salguero
Jun 26, 2020·Frontiers in Veterinary Science·Maria Luisa DanzettaFrancesco Feliziani
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Jul 3, 2021·Viruses·Katja SchulzCarola Sauter-Louis
Oct 1, 2021·Transboundary and Emerging Diseases·Gustavo MachadoCristina Lanzas

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