Evolution of 8p loss in transformed human prostate epithelial cells

Cancer Genetics and Cytogenetics
Jill A MacoskaJeremy A Squire

Abstract

Deletion or rearrangement of sequences that map to the short arm of chromosome 8 (8p) are frequently associated with human prostate tumorigenesis. These losses often involve the entire short arm of chromosome 8 or very large regions of distal or proximal 8p, and several putative tumor suppressor genes mapping to 8p have been described. However, the mechanism responsible for 8p loss during prostate tumorigenesis has not been elucidated. In this study, we report data obtained using array comparative genomic hybridization and spectral karyotyping, which demonstrate successive translocation and deletion events responsible for loss of one copy of 8p in transformed human prostate epithelial cells. Moreover, this loss was accompanied by a pronounced transcriptional downregulation of genes mapping to the remaining copy of 8p and enhanced expression of traits associated with neoplastic transformation. Taken together, these studies illustrate a potential mechanism and functional role for 8p loss in human prostate tumorigenesis.

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Citations

Feb 29, 2008·Nucleic Acids Research·Francesca DemichelisMark A Rubin
Nov 23, 2012·PloS One·Mehrnaz Gharaee-KermaniJill A Macoska
Oct 30, 2009·The Prostate·Kristy L McDowellJill A Macoska
Sep 9, 2009·Cell Proliferation·S KasinaJ A Macoska
May 3, 2006·Molecular and Cellular Endocrinology·M Di BenedettoC Nahmias
Jan 16, 2007·Neoplasia : an International Journal for Oncology Research·Pamela L ParisColin Collins
May 10, 2012·The American Journal of Pathology·Yan P YuJian-Hua Luo
Jul 2, 2016·PloS One·Mehrnaz Gharaee-KermaniJill A Macoska
Jul 17, 2007·The Journal of Biological Chemistry·Lesa A BegleyJill A Macoska

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