PMID: 9653084Jul 7, 1998Paper

Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection

The Journal of Experimental Medicine
D H BuschE G Pamer

Abstract

The mechanisms underlying the genesis and maintenance of T cell memory remain unclear. In this study, we examined the evolution of a complex, antigen-specific T cell population during the transition from primary effector to memory T cells after Listeria monocytogenes infection. T cell populations specific for listeriolysin O (LLO)91-99, the immunodominant epitope recognized by H2-Kd-restricted T lymphocytes, were directly identified in immune spleens using tetrameric H2-Kd-epitope complexes. The T cell receptor (TCR) Vbeta repertoire of specific T cells was determined by direct, ex vivo staining with a panel of mAbs. We demonstrate that LLO91-99-specific, primary effector T cell populations have a diverse TCR Vbeta repertoire. Analyses of memory T cell populations demonstrated similar TCR diversity. Furthermore, experiments with individual mice demonstrated that primary effector and memory T cells have indistinguishable TCR repertoires. Remarkably, after reinfection with L. monocytogenes, LLO91-99-specific T cells have a narrower TCR repertoire than do primary effector or memory T cells. Thus, our studies show that the TCR repertoire of primary effector T lymphocytes is uniformly transmitted to memory T cells, whereas expansion...Continue Reading

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Citations

Jul 2, 1999·Springer Seminars in Immunopathology·M F Callan, A J McMichael
Jan 21, 2010·Immunologic Research·Simona StägerRashmi Bankoti
Apr 20, 2004·Journal of Theoretical Biology·Dennis L ChaoAlan S Perelson
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Feb 27, 1999·Current Opinion in Immunology·J T Harty, M J Bevan
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May 31, 2001·Vox Sanguinis·J L SchultzeR H Vonderheide
May 15, 2001·Immunology and Cell Biology·M Regner
Dec 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Evan R JellisonLeo Lefrançois
Feb 17, 1999·The Journal of Experimental Medicine·D H Busch, E G Pamer
Aug 4, 1999·The Journal of Experimental Medicine·K M KerksiekE G Pamer
Nov 2, 1999·The Journal of Experimental Medicine·J B HaanenT N Schumacher
Mar 6, 2002·The Journal of Experimental Medicine·Joseph N BlattmanRafi Ahmed
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Jul 25, 2006·Infection and Immunity·Dennis M LindellGary B Huffnagle
Jun 13, 2001·Infection and Immunity·N V Serbina, J L Flynn

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