Evolution of a fetal expression pattern via cis changes near the gamma globin gene.

The Journal of Biological Chemistry
C TomHonD L Gumucio

Abstract

One basis for the evolution of organisms is the acquisition of new temporal and spatial domains of gene expression. Such novel expression domains could be generated either by cis sequence changes that alter the complement of trans-acting regulators binding to control elements or by changes in the expression patterns of one or more of the regulatory (trans) factors themselves. The gamma globin gene is a prime example of a gene that has undergone a distinct change in temporal expression at a defined time in evolution. Approximately 35-55 million years ago, the previously embryonic gamma gene acquired a fetal expression pattern. This change occurred in a simian primate ancestor after the separation of simian and prosimian primates but before the further separation of the major simian lineages; thus, the (prosimian) galago gamma gene retains the ancestral embryonic expression pattern, whereas the (simian) human gamma gene is fetal. This analysis of galago and human gamma genes in transgenic mice demonstrates that cis changes in sequences within a 4.0-kilobase region surrounding the gamma gene were responsible for the evolution of a novel fetal expression pattern in the gamma globin genes of simian primates.

References

Aug 1, 1991·Genes & Development·O HanscombeF Grosveld
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D H FitchJ L Slightom
Mar 1, 1989·The Journal of Clinical Investigation·T J LeyA L Schwartz
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B F Koop, M Goodman
Jan 1, 1987·Cold Spring Harbor Symposia on Quantitative Biology·M GoodmanJ L Slightom
Jan 1, 1981·Progress in Biophysics and Molecular Biology·M Goodman
Dec 25, 1984·Journal of Molecular Biology·M GoodmanM L Weiss
Sep 1, 1995·Trends in Genetics : TIG·E Dzierzak, A Medvinsky
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S J Cooper, R M Hope
Aug 1, 1993·Molecular and Cellular Biology·K R Peterson, G Stamatoyannopoulos
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K R PetersonG Stamatoyannopoulos

❮ Previous
Next ❯

Citations

Jan 6, 2001·The Journal of Experimental Zoology·R M JohnsonM Goodman
Feb 26, 2005·Experimental Hematology·George Stamatoyannopoulos
Aug 5, 1998·Current Opinion in Genetics & Development·R A Swank, G Stamatoyannopoulos
Nov 22, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Robert M JohnsonMorris Goodman
Jun 20, 2006·Molecular and Cellular Biology·Man YuGeorge Stamatoyannopoulos
Feb 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert M JohnsonMorris Goodman
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Qiliang LiGeorge Stamatoyannopoulos
Oct 7, 2006·Human Mutation·Hildegard Kehrer-Sawatzki, David N Cooper
Apr 24, 2007·The Journal of Experimental Biology·Patricia J Wittkopp
Jan 23, 1999·American Journal of Human Genetics·M Goodman

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.