Evolution of a rapid onsite evaluation (ROSE) service for endobronchial ultrasound guided (EBUS) fine needle aspiration (FNA) cytology in a UK Hospital: A 7 year audit

Diagnostic Cytopathology
Tracey StevensonChristopher Bowles

Abstract

Endobronchial ultrasound fine needle aspiration (EBUS FNA) is a well-established procedure for the diagnosis and staging of lung cancer. We review our provision of this service at the Royal Devon and Exeter NHS Foundation Trust and the role of rapid onsite evaluation (ROSE) with the increasing demand for molecular markers in this era of personalized medicine. A review of the changes in the Endoscopy clinic over the 7 years from the introduction of EBUS at the end of 2010 until 2017 was carried out. This included the availability of material obtained for diagnosis, accurate subtyping, and molecular testing. We also assessed the success of molecular genetics DNA techniques from EBUS material versus formalin fixed paraffin embedded tissue (FFPE). A total of 1218 EBUS cases with ROSE were reported between 2011 and 2017 Percentage diagnostic rates were calculated as 83, 82, 84, 92, 93, 94, and 92 for 2011, 2012, 2013, 2014, 2015, 2016, and 2017, respectively. Availability of material for immunocytochemistry ranged from 86 to 100% over the 7 years. Molecular testing was successfully performed for EGFR in 89-100% of requested cases and ALK testing in 87-100% of requested cases. EBUS sourced material gave on average twice the amount of...Continue Reading

References

Sep 17, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·G KocjanP Wilson
Dec 18, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·S E H CameronS E Pambuccian
Sep 30, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jordan P ReynoldsJoseph C Cicenia
Feb 27, 2016·Cytopathology : Official Journal of the British Society for Clinical Cytology·S A ThiryayiS Bailey

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Citations

Dec 15, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Leonie GlinskiJames Garvican
Jan 3, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer Brainard, Carol Farver
Feb 6, 2020·American Journal of Respiratory and Critical Care Medicine·Gerard J CrinerFelix J Herth
Feb 20, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Winnie TangAnthony Maddox
Jun 3, 2021·International Journal of Molecular Sciences·Alessandro CaputoAntonio D'Antonio
Oct 31, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Anthony Maddox, Louise M Smart
Dec 22, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Alina MirandaMichelle Kelly

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