PMID: 9420239Jan 7, 1998Paper

Evolution of a simian immunodeficiency virus pathogen

Journal of Virology
P EdmonsonJ I Mullins

Abstract

Analysis of disease induction by simian immunodeficiency viruses (SIV) in macaques was initially hampered by a lack of molecularly defined pathogenic strains. The first molecularly cloned SIV strains inoculated into macaques, SIVmacBK28 and SIVmacBK44 (hereafter designated BK28 and BK44, respectively), were cases in point, since they failed to induce disease within 1 year postinoculation in any inoculated animal. Here we report the natural history of infection with BK28 and BK44 in inoculated rhesus macaques and efforts to increase the pathogenicity of BK28 through genetic manipulation and in vivo passage. BK44 infection resulted in no disease in four animals infected for more than 7 years, whereas BK28 induced disease in less than half of animals monitored for up to 7 years. Elongation of the BK28 transmembrane protein (TM) coding sequence truncated by prior passage in human cells marginally increased pathogenicity, with two of four animals dying in the third year and one dying in the seventh year of infection. Modification of the BK28 long terminal repeat to include four consensus nuclear factor SP1 and two consensus NF-kappaB binding sites enhanced early virus replication without augmenting pathogenicity. In contrast, in viv...Continue Reading

References

Sep 25, 1992·Nucleic Acids Research·P F Edmonson, J I Mullins
Nov 15, 1991·Science·M A NowakR M May
Oct 19, 1989·Nature·V M HirschJ I Mullins
Nov 1, 1989·Journal of Virology·T KodamaR C Desrosiers
Dec 1, 1987·The Journal of General Virology·M D DanielR C Desrosiers
Jun 7, 1985·Science·M D DanielR C Desrosiers
Jan 1, 1994·AIDS Research and Human Retroviruses·S OhkawaM Murphey-Corb
Jun 1, 1996·Journal of Medical Primatology·A Martin AmedeeM Murphey-Corb

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Citations

May 6, 1999·Nature Medicine·V M Hirsch
Jun 9, 2005·Reviews in Medical Virology·Tim van Opijnen, Ben Berkhout
Dec 29, 2010·PLoS Pathogens·Marcel E CurlinJames I Mullins
Sep 25, 1998·Journal of Medical Primatology·T MulvaniaJ I Mullins
Aug 3, 2004·Expert Review of Vaccines·James I MullinsGerald H Learn

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