Evolution of a Strategy for the Enantioselective Synthesis of (-)-Cajanusine.

Journal of the American Chemical Society
Renyu GuoM Kevin Brown

Abstract

The first enantioselective synthesis of (-)-cajanusine is presented. Key features of the route include a rapid synthesis of the [4.2.0]bicyclooctane core by an enantioselective isomerization/stereoselective [2+2]-cycloaddition strategy as well as prominent use of catalytic methods for bond construction. The evolution of the approach is also presented that highlights unexpected roadblocks and how novel solutions were developed.

References

Aug 14, 2003·Chemical Reviews·Tamio Hayashi, Kaori Yamasaki
Aug 19, 2004·Journal of the American Chemical Society·David NecasMartin Kotora
May 9, 2009·Journal of the American Chemical Society·Hongjun LiuChoon-Hong Tan
Jun 26, 2009·Natural Product Reports·Tao ShenHong-Xiang Lou
Aug 25, 2011·Journal of the American Chemical Society·Jessica M Hoover, Shannon S Stahl
Mar 11, 2015·Journal of the American Chemical Society·Michael L ConnerM Kevin Brown
Feb 3, 2016·Journal of the American Chemical Society·Josep CornellaPhil S Baran
Apr 1, 2016·Journal of the American Chemical Society·Kierra M M HuihuiDaniel J Weix
Jun 9, 2016·Chemistry : a European Journal·Lukiana L Anka-LuffordDaniel J Weix
Aug 23, 2016·Journal of the American Chemical Society·Fumihiko ToriyamaPhil S Baran
Feb 12, 2017·Angewandte Chemie·Frederik SandfortPhil S Baran
Feb 21, 2018·Chemical Reviews·Xing-Wei YangGang Xu
Nov 6, 2018·Journal of the American Chemical Society·Johannes M WahlM Kevin Brown
Apr 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ming ShangPhil S Baran
Apr 26, 2019·Nature·Pengfei HuScott A Snyder

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