Evolution of adaptation mechanisms: Adaptation energy, stress, and oscillating death

Journal of Theoretical Biology
Alexander N GorbanLyudmila I Pokidysheva

Abstract

In 1938, Selye proposed the notion of adaptation energy and published 'Experimental evidence supporting the conception of adaptation energy.' Adaptation of an animal to different factors appears as the spending of one resource. Adaptation energy is a hypothetical extensive quantity spent for adaptation. This term causes much debate when one takes it literally, as a physical quantity, i.e. a sort of energy. The controversial points of view impede the systematic use of the notion of adaptation energy despite experimental evidence. Nevertheless, the response to many harmful factors often has general non-specific form and we suggest that the mechanisms of physiological adaptation admit a very general and nonspecific description. We aim to demonstrate that Selye׳s adaptation energy is the cornerstone of the top-down approach to modelling of non-specific adaptation processes. We analyze Selye׳s axioms of adaptation energy together with Goldstone׳s modifications and propose a series of models for interpretation of these axioms. Adaptation energy is considered as an internal coordinate on the 'dominant path' in the model of adaptation. The phenomena of 'oscillating death' and 'oscillating remission' are predicted on the base of the dyn...Continue Reading

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Citations

Jul 11, 2016·Journal of Theoretical Biology·Andrew Morozov
Dec 9, 2016·PloS One·Angélique O J CramerDenny Borsboom
Jun 3, 2017·The Journal of Physical Chemistry. B·Gunhild FjeldPeter Ruoff
Sep 11, 2019·International Journal of Molecular Sciences·Nicolas SompairacAndrei Zinovyev
Mar 21, 2018·Bulletin of Mathematical Biology·Ivan TyukinValeri A Makarov
Mar 26, 2021·Physics of Life Reviews·A N GorbanE V Smirnova

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