Evolution of ageing since Darwin.

Journal of Genetics
M RoseLaurence D Mueller

Abstract

In the late 19th century, the evolutionary approach to the problem of ageing was initiated by August Weismann, who argued that natural selection was more important for ageing than any physiological mechanism. In the mid-twentieth century, J. B. S. Haldane, P. B. Medawar and G. C. Williams informally argued that the force of natural selection falls with adult age. In 1966, W. D. Hamilton published formal equations that showed mathematically that two 'forces of natural selection' do indeed decline with age, though his analysis was not genetically explicit. Brian Charlesworth then developed the required mathematical population genetics for the evolution of ageing in the 1970's. In the 1980's, experiments using Drosophila showed that the rate of ageing evolves as predicted by Hamilton's 'forces of natural selection'. The discovery of the cessation of ageing late in life in the 1990's was followed by its explanation in terms of evolutionary theory based on Hamilton's forces. Recently, it has been shown that the cessation of ageing can also be manipulated experimentally using Hamilton's 'forces of natural selection'. Despite the success of evolutionary research on ageing, mainstream gerontological research has largely ignored both th...Continue Reading

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Citations

Oct 25, 2013·Chinese Journal of Integrative Medicine·Zhi-Guo ZhangGary Guishan Xiao
Apr 9, 2013·Bio Systems·Andres Kriete
Jan 19, 2012·Nutrients·Roger B McDonald, Rodney C Ruhe
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May 28, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kang Hao CheongMichael C Jones
Jun 21, 2020·Scientific Reports·Richard M CawthonLynn B Jorde

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