Evolution of an epigenetic gene ensemble within the genus Anopheles

Genome Biology and Evolution
Adam M Jenkins, Marc A T Muskavitch

Abstract

Epigenetic control of gene expression has important implications for the regulation of developmental processes, for mediating homeostasis and responses to the external environment, and for transgenerational inheritance of gene expression patterns. Genes that mediate epigenetic control have been well-characterized in Drosophila melanogaster, and we have identified and analyzed an orthologous gene ensemble in Anopheles gambiae that comprises 169 orthologs related to a 215-member epigenetic gene ensemble in D. melanogaster. We find that this ensemble is highly conserved among anopheline mosquitoes, as we identify only seven gene family expansion/contraction events within the ensemble among 12 mosquito species we have studied within the genus Anopheles. Comparative analyses of the epigenetic gene expression across the genera Drosophila and Anopheles reveal distinct tissue-associated expression patterns in the two genera, but similar temporal expression patterns. The A. gambiae complex and D. melanogaster subgroup epigenetic gene ensembles exhibit similar evolutionary rates, as assessed by their respective dN/dS values. These differences in tissue-associated expression patterns, in contrast to similarities in evolutionary rates and ...Continue Reading

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Citations

Jun 23, 2015·Current Opinion in Insect Science·Igor V Sharakhov, Maria V Sharakhova
Apr 18, 2018·Immunological Reviews·Benjamin GourbalMihai G Netea
Jan 30, 2020·Frontiers in Immunology·Fabiola Claudio-PiedrasHumberto Lanz-Mendoza

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Datasets Mentioned

BETA
PRJNA236161

Methods Mentioned

BETA
histone acetylation
RNAseq
acetylation
ubiquitination
PCA

Software Mentioned

MRBB
CLUSTAL Omega
RAxML
R Team
CuffDiff
modENCODE
TopHat2
TBLASTN
eggNOG
trimAl

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