Evolution of bacteriophages infecting encapsulated bacteria: lessons from Escherichia coli K1-specific phages

Molecular Microbiology
Katharina StummeyerMartina Mühlenhoff

Abstract

Bacterial capsules are not only important virulence factors, but also provide attachment sites for bacteriophages that possess capsule degrading enzymes as tailspike proteins. To gain insight into the evolution of these specialized viruses, we studied a panel of tailed phages specific for Escherichia coli K1, a neuroinvasive pathogen with a polysialic acid capsule. Genome sequencing of two lytic K1-phages and comparative analyses including a K1-prophage revealed that K1-phages did not evolve from a common ancestor. By contrast, each phage is related to a different progenitor type, namely T7-, SP6-, and P22-like phages, and gained new host specificity by horizontal uptake of an endosialidase gene. The new tailspikes emerged by combining endosialidase domains with the capsid binding module of the respective ancestor. For SP6-like phages, we identified a degenerated tailspike protein which now acts as versatile adaptor protein interconnecting tail and newly acquired tailspikes and demonstrate that this adapter utilizes an N-terminal undecapeptide interface to bind otherwise unrelated tailspikes. Combining biochemical and sequence analyses with available structural data, we provide new molecular insight into basic mechanisms that a...Continue Reading

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Related Concepts

Endo-N-acetylneuraminidase F
Tailspike protein, bacteriophage
Coliphages
Alkalescens-Dispar Group
Biological Evolution
Neuraminidase
Viral Envelope Proteins gp70
Bacterial Capsules
Viral Genome
Viral Tail Proteins

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