Evolution of chronic nitric oxide inhibition hypertension: relationship to renal function

Hypertension
C QiuC Baylis

Abstract

We conducted longitudinal measurements of blood pressure and renal function in the conscious, chronically catheterized rat before and during acute nitric oxide synthase inhibition (N-nitro-L-arginine methylester [L-NAME], 37 micromol/kg IV) and then chronic administration of oral L-NAME (approximately 37 micromol/kg per 24 hours). These studies specifically investigate the impact on plasma and renal renin as well as volume status during the evolution of this hypertension in rats not subjected to acute experimental stress. Blood pressure progressively increased with chronic administration of L-NAME and reached values greatly above those seen with acute administration of L-NAME. There were parallel increases in renal vascular resistance and development of proteinuria, and glomerular filtration rate began to decline at day 21, coincident with the appearance of renal damage. Twenty-four-hour urinary nitrite and nitrate excretion remained depressed, reflecting reduced nitric oxide synthesis. The plasma renin activity was variable and only increased transiently at 21 days, thus the angiotensin II dependence of this hypertension is not caused by stimulated plasma renin activity. Despite severe hypertension, sodium intake and excretion...Continue Reading

References

Dec 1, 1992·American Journal of Hypertension·R A Johnson, R H Freeman
Dec 1, 1991·The American Journal of Physiology·J G WongD E Johnson
Dec 1, 1990·Journal of the American Society of Nephrology : JASN·C BaylisK Engels
Jul 1, 1995·The American Journal of Physiology·Z KarimJ Poggioli
Feb 1, 1993·The American Journal of Physiology·P A NemethP M Nemeth
Jun 1, 1997·Kidney International·P L TharauxC Chatziantoniou

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Citations

Nov 27, 2004·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·V ThirunavukkarasuC V Anuradha
Jul 20, 2004·Current Hypertension Reports·Nosratola D Vaziri, Domenic A Sica
Dec 3, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Kazim Husain
Aug 27, 2005·Mitochondrion·Leopoldo Aguilera-AguirreAlfredo Saavedra-Molina
Jun 26, 2001·Clinical and Experimental Pharmacology & Physiology·M A CostaC T Arranz
Aug 8, 2002·Clinical and Experimental Pharmacology & Physiology·Maria de los Angeles CostaC T Arranz
Sep 5, 2001·Kidney International·C H BartonN D Vaziri
Feb 8, 2003·Antioxidants & Redox Signaling·Victoria CachofeiroJoaquín García-Estañ
Jan 23, 1999·Current Opinion in Nephrology and Hypertension·M Sander, R G Victor
Dec 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aaron ErdelyChris Baylis
Dec 18, 1998·Hypertension·R Zatz, C Baylis
Oct 12, 2010·Indian Journal of Pharmacology·Elvine Pami Nguelefack-MbuyoAlbert Kamanyi
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrew S CowburnRandall S Johnson
Jul 12, 2002·Clinical and Experimental Hypertension : CHE·Ja-Ryong KooNosratola D Vaziri
Oct 13, 2006·Clinical and Experimental Hypertension : CHE·Timoleon VyzantiadisChrysanthos Zamboulis
Nov 27, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Steven K Engle, David E Watson
Sep 13, 2003·Kidney International. Supplement·Leopoldo G ArdilesSergio A Mezzano
Mar 28, 2009·European Journal of Pharmacology·Frédérick TherrienRichard Larivière
Dec 4, 2008·Fundamental & Clinical Pharmacology·Ashraf BahgatMohamed T Khayyal
Jan 7, 2006·Phytotherapy Research : PTR·Z Celebi KoçyildizA H Meriçli
Mar 12, 2015·Canadian Journal of Physiology and Pharmacology·Elizabeth Alejandrina Guzmán-HernándezMaximiliano Ibarra-Barajas
Oct 25, 2011·Journal of Cardiovascular Disease Research·Gazalla Ayub ShiekhKhurshid Iqbal Andrabi
Aug 17, 2000·Nitric Oxide : Biology and Chemistry·D T Lowe
Jul 11, 2009·The Journal of International Medical Research·H BuyukhatipogluC Usalan
Dec 18, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A M BalaszczukC Arranz
Apr 10, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ivan T DemchenkoClaude A Piantadosi
Dec 9, 1998·The American Journal of Physiology·A Kurtz, C Wagner
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·Y DingD D Roh
Jul 3, 2003·American Journal of Physiology. Renal Physiology·Loudes A FortepianiJ Carlos Romero
Jul 24, 2003·American Journal of Physiology. Renal Physiology·Ali A KhraibiDaiyi Tang
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·S M Fitzgerald, M W Brands
Oct 21, 2000·American Journal of Hypertension·C Qiu, C Baylis
May 25, 2001·Journal of the American Society of Nephrology : JASN·Erdmann SeeligerH Wolfgang Reinhardt

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