Evolution of complexity in miRNA-mediated gene regulation systems

Trends in Genetics : TIG
Shohei Takuno, Hideki Innan

Abstract

Using Arabidopsis microRNA (miRNA)-mediated gene regulation system as a model, we investigated how complex systems evolve with special attention to selection to maintain the systems. We found that the copy number of miRNA genes within each system is a key factor to determine the complexity of the system, indicating a crucial role of gene duplication to increase the complexity. Furthermore, we show that the mode of selection to maintain the systems depend on their complexity levels.

References

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Citations

Aug 30, 2008·Genome Biology·Jingjing LiZhaolei Zhang
Aug 16, 2008·Expert Reviews in Molecular Medicine·Erica Hennessy, Lorraine O'Driscoll
Apr 12, 2011·Molecular Biology and Evolution·Shohei Takuno, Hideki Innan
Jan 18, 2016·Trends in Biotechnology·Sachin TeotiaGuiliang Tang
Feb 7, 2012·Current Opinion in Plant Biology·Riet De Smet, Yves Van de Peer
Jul 24, 2012·Journal of Theoretical Biology·Tetsuya AkitaHideki Innan

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