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Evolution of Conditional Cooperativity Between HOXA11 and FOXO1 Through Allosteric Regulation

bioRxiv

Jan 26, 2015

Mauris C. NnamaniGünter Paul Wagner

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Abstract

Transcription factors (TFs) play multiple roles in different cells and stages of development. Given this multitude of functional roles it has been assumed that TFs are evolutionarily highly constrained. Here we investigate the molecular mechanisms for the origin of a derived functional ...read more

Mentioned in this Paper

Study
HOXA11 gene
Stromal Cell of Endometrium
Stromal Cells
Protein complex
Structure
Forkhead Box Protein O1
FOXO1 gene
Protein Complex Location
Transcription Factor
13
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  • Evolution of Conditional Cooperativity Between HOXA11 and FOXO1 Through Allosteric Regulation

    bioRxiv

    Jan 26, 2015

    Mauris C. NnamaniGünter Paul Wagner

    PMID: 990014381

    DOI: 10.1101/014381

    Abstract

    Transcription factors (TFs) play multiple roles in different cells and stages of development. Given this multitude of functional roles it has been assumed that TFs are evolutionarily highly constrained. Here we investigate the molecular mechanisms for the origin of a derived functional ...read more

    Mentioned in this Paper

    Study
    HOXA11 gene
    Stromal Cell of Endometrium
    Stromal Cells
    Protein complex
    13

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