Evolution of Early SARS-CoV-2 and Cross-Coronavirus Immunity

MSphere
Carolin LoosGalit Alter

Abstract

The novel coronavirus, SARS-coronavirus (CoV)-2 (SARS-CoV-2), has caused over 17 million infections in just a few months, with disease manifestations ranging from largely asymptomatic infection to critically severe disease. The remarkable spread and unpredictable disease outcomes continue to challenge management of this infection. Among the hypotheses to explain the heterogeneity of symptoms is the possibility that exposure to other coronaviruses (CoVs), or overall higher capability to develop immunity against respiratory pathogens, may influence the evolution of immunity to SARS-CoV-2. Thus, we profiled the immune response across multiple coronavirus receptor binding domains (RBDs), respiratory viruses, and SARS-CoV-2, to determine whether heterologous immunity to other CoV-RBDs or other infections influenced the evolution of the SARS-CoV-2 humoral immune response. Overall changes in subclass, isotype, and Fc-receptor binding were profiled broadly across a cohort of 43 individuals against different coronaviruses-RBDs of SARS-CoV-2 and the more common HKU1 and NL63 viruses. We found rapid functional evolution of responses to SARS-CoV-2 over time, along with broad but relatively more time-invariant responses to the more common C...Continue Reading

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Nov 11, 2020·Journal of Clinical Medicine·Lisandru CapaiAlessandra Falchi
Jan 22, 2021·Nature Reviews. Gastroenterology & Hepatology·Ferdinando D'AmicoSilvio Danese
Feb 17, 2021·Nature Communications·Yannic C BartschGalit Alter
Apr 10, 2021·Frontiers in Immunology·Antonio ArenasAntonio Arenas-Montes
Apr 6, 2021·Frontiers in Immunology·Jaime Fergie, Amit Srivastava
Apr 30, 2021·Journal of Medical Virology·Susannah LeachMagnus Gisslén
Jun 1, 2021·Cell Reports Medicine·Andrea R ShiakolasIvelin S Georgiev

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay

Software Mentioned

R package ‘ ropls ’

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