Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes

PLoS Genetics
Jessica E SpiewakDavid M Parichy

Abstract

Fishes of the genus Danio exhibit diverse pigment patterns that serve as useful models for understanding the genes and cell behaviors underlying the evolution of adult form. Among these species, zebrafish D. rerio exhibit several dark stripes of melanophores with sparse iridophores that alternate with light interstripes of dense iridophores and xanthophores. By contrast, the closely related species D. nigrofasciatus has an attenuated pattern with fewer melanophores, stripes and interstripes. Here we demonstrate species differences in iridophore development that presage the fully formed patterns. Using genetic and transgenic approaches we identify the secreted peptide Endothelin-3 (Edn3)-a known melanogenic factor of tetrapods-as contributing to reduced iridophore proliferation and fewer stripes and interstripes in D. nigrofasciatus. We further show the locus encoding this factor is expressed at lower levels in D. nigrofasciatus owing to cis-regulatory differences between species. Finally, we show that functions of two paralogous loci encoding Edn3 have been partitioned between skin and non-skin iridophores. Our findings reveal genetic and cellular mechanisms contributing to pattern differences between these species and suggest ...Continue Reading

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Citations

Oct 27, 2018·Science·Hugo F Gante
Sep 18, 2020·Nature·Tyler A SquareDaniel M Medeiros
May 30, 2019·ELife·Lauren M SaundersDavid M Parichy
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May 25, 2021·The Journal of Heredity·Chenxu WangDeshou Wang
May 26, 2021·Proceedings of the National Academy of Sciences of the United States of America·Pauline SalisVincent Laudet
May 15, 2021·Genome Biology and Evolution·Pietro Longo Hollanda de MelloRichard E Glor
Jan 7, 2020·Current Biology : CB·Anastasia EskovaUwe Irion

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Methods Mentioned

BETA
transgenic
PCR

Software Mentioned

ZEN blue
JMP
Axiovision

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