PMID: 9188572Jul 1, 1997Paper

Evolution of envelope-specific antibody responses in monkeys experimentally infected or immunized with simian immunodeficiency virus and its association with the development of protective immunity

Journal of Virology
K S ColeR C Montelaro

Abstract

Previous studies of attenuated simian immunodeficiency virus (SIV) vaccines in rhesus macaques have demonstrated the development of broad protection against experimental challenge, indicating the potential for the production of highly effective immune responses to SIV antigens. However, the development of this protective immune status was found to be critically dependent on the length of time postvaccination with the attenuated virus strain, suggesting a necessary maturation of immune responses. In this study, the evolution of SIV envelope-specific antibodies in monkeys experimentally infected with various attenuated strains of SIV was characterized by using a comprehensive panel of serological assays to assess the progression of antibodies in longitudinal serum samples that indicate the development of protective immunity. In parallel studies, we also used the same panel of antibody assays to characterize the properties of SIV envelope-specific antibodies elicited by inactivated whole-virus and envelope subunit vaccines previously reported to be ineffective in producing protective immunity. The results of these studies demonstrate that the evolution of protective immunity in monkeys inoculated with attenuated strains of SIV is ...Continue Reading

References

Jun 1, 1992·Journal of Clinical Microbiology·O MeurmanK Hedman
Feb 1, 1991·Journal of Medical Virology·H O KangroD R Harper
Aug 1, 1991·Current Opinion in Immunology·A A Salmi
Oct 3, 1991·Nature·E J Stott
Feb 1, 1991·Journal of Virological Methods·H I Thomas, P Morgan-Capner
Mar 31, 1990·Lancet·T G WreghittJ A Barbara
Nov 1, 1990·AIDS Research and Human Retroviruses·D A Regier, R C Desrosiers
Jan 1, 1990·Annual Review of Immunology·R C Desrosiers
Jun 18, 1988·Lancet·P Morgan-Capner, H I Thomas
May 1, 1988·Journal of Clinical Immunology·K Hedman, I Seppälä
Jan 1, 1994·Journal of Clinical Laboratory Analysis·J PolanecK Hedman
Jan 12, 1996·Science·R M Zinkernagel
Feb 1, 1996·Clinical and Experimental Immunology·H I ThomasP Morgan-Capner
Jun 1, 1996·Journal of Virology·M S WyandR C Desrosiers
Jun 1, 1996·Journal of Virology·S LuH L Robinson

❮ Previous
Next ❯

Citations

Nov 24, 1999·Immunological Reviews·R M Ruprecht
Dec 11, 1999·Journal of Medical Primatology·N Nathanson, B J Mathieson
Feb 15, 2001·AIDS Research and Human Retroviruses·B S ParekhJ S McDougal
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Surojit SarkarRonald C Montelaro
Jan 11, 2008·AIDS Research and Human Retroviruses·Lianxing LiuYiming Shao
Aug 3, 2010·AIDS Research and Human Retroviruses·Jessica S ThomasAngela M Amedee
Oct 19, 2011·The Journal of Clinical Investigation·Alexandra M OrtizGuido Silvestri
Sep 22, 2017·Journal of Virology·Egidio Brocca-CofanoIvona Pandrea
Jun 18, 1999·Reviews in Medical Virology·A M Geretti
Dec 14, 2004·AIDS Research and Human Retroviruses·Kelly R YoungTed M Ross
Jun 9, 2009·AIDS Research and Human Retroviruses·Yanmin WanJianqing Xu
Apr 6, 2012·The New England Journal of Medicine·Barton F HaynesJerome H Kim
Apr 22, 2005·Medical Microbiology and Immunology·Klaus Uberla
Oct 4, 2000·Viral Immunology·J M SmithJ V Torres

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.