PMID: 9186826May 1, 1997Paper

Evolution of hepatitis C virus quasispecies in mothers and infants infected through mother-to-infant transmission

Journal of Hepatology
Y H NiH Y Hsu

Abstract

Two mother-infant pairs (Pair H and P) were studied to determine the evolution of hepatitis C virus (HCV) quasispecies. Eight clones of the hypervariable region of HCV cDNA from the infants' sera sampled at the age of 3 months, 1, 2, and 3 years and the time-corresponding maternal sample were also sequenced. The sequences were analyzed by the nucleotide diversity, substitution rate, and phylogenetic studies. HCV quasispecies of the infants were more homogeneous than those of their mothers, particularly at the age of 3 months (nucleotide diversity, pi = 0.18 x 10(-2)/site in infant H, and 0.22 x 10(-2)/site in infant P). The nucleotide substitution rate in infants also increased as they aged, from 1.2 x 10(-2) to 4.46 x 10(-2)/site/year in infant H, and from 0.21 x 10(-2) to 4.88 x 10(-2)/site/year in infant P respectively. The nucleotide sequence differences between infants and mothers increased from 2.63 x 10(-2) to 9.06 x 10(-2)/site in Pair H, and from 1.85 x 10(-2) to 5.33 x 10(-2)/site in Pair P within 3 years. Phylogenetic studies suggest the infants' initial quasispecies were closely related to their mothers', while they evolved differently. HCV RNA titer was stable during follow-up and the infants' titer was similar to ...Continue Reading

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Citations

May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M TsiangC S Gibbs
Sep 5, 2002·Journal of Medical Virology·Guang GaoEdward Tabor
Jan 6, 2000·Journal of Hepatology·M Ruiz-MorenoA Millàn
Jun 26, 1998·Journal of Gastroenterology and Hepatology·M H Chang
Mar 16, 2005·Journal of Virology·Belinda L HerringEric L Delwart
Aug 12, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sarah L Fishman, Andrea D Branch
May 25, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Tsutomu IshiiHiroaki Okamoto
Apr 29, 1998·The Tohoku Journal of Experimental Medicine·R LiY Wada
Dec 19, 2013·Journal of Pediatric Gastroenterology and Nutrition·Jessica W Wen, Barbara A Haber
Oct 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mikhail I KatsnelsonEugene V Koonin
Jan 4, 2001·Clinical and Diagnostic Laboratory Immunology·K A Harris, C G Teo
Aug 14, 2002·World Journal of Gastroenterology : WJG·Song Chen, Yu-Ming Wang

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