PMID: 6402305Jan 1, 1983Paper

Evolution of immunoglobulin V genes: evidence indicating that recently duplicated human V kappa sequences have diverged by gene conversion

Cell
D L Bentley, T H Rabbitts

Abstract

We have analyzed several closely related members of the gene family encoding the variable regions of human immunoglobulin kappa light chains (V kappa genes). Two of these genes differ at a single nucleotide out of 940 bases sequenced, and are believed to be alleles of a locus called HK 101. This substitution results in an amino acid replacement in the first complementarity-determining region of the kappa chain. We also compared the structures of two nonallelic human V kappa loci (HK 101 and HK 137) and found a high degree of sequence homology over a region at least 13.5 kb long. This long block of homology indicates that these two loci arose from a recent gene duplication. The DNA sequences of these two nonallelic V kappa genes exhibit a very unusual distribution of nucleotide substitutions. Seven of the ten substitutions found among 940 bases are clustered in a 39 base stretch encoding the first complementarity-determining region and the second framework region of the protein. We suggest that this cluster of substitutions was generated by a gene conversion in which a small segment of one gene was replaced with the homologous segment from another V kappa gene.

References

May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E A KabatH Bilofsky
Oct 6, 1978·Science·J G SeidmanP Leder
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·J D CapraA Nisonoff
Jan 1, 1981·CRC Critical Reviews in Biochemistry·C Brack
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P H SchreierD Baltimore
Mar 25, 1982·Nucleic Acids Research·D L BentleyT H Rabbitts
Jan 24, 1981·Nucleic Acids Research·J MessingP H Seeburg
Oct 25, 1980·Journal of Molecular Biology·F SangerB A Roe
Apr 24, 1981·Nucleic Acids Research·D Westaway, R Williamson
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J F ErnstF Sherman
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G Matthyssens, T H Rabbitts
Jul 30, 1981·Nature·D GivolJ B Cohen
May 1, 1982·The Journal of Experimental Medicine·O W McBrideP Leder
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S MalcolmT H Rabbitts
Oct 1, 1981·Cell·S H ShenO Smithies
May 1, 1965·Journal of Clinical Pathology·J V PULVERTAFT

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Citations

Nov 1, 1988·Molecular & General Genetics : MGG·P GarciaM Sicard
Sep 1, 1984·Molecular and Cellular Biochemistry·L H Caporale
Jan 1, 1987·Immunogenetics·E Lamoyi, R Mage
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·A CarboneM Boiocchi
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·A CarboneM Boiocchi
Jan 1, 1987·Journal of Molecular Evolution·G A Dover
Aug 5, 1988·Journal of Molecular Biology·G A RathbunP W Tucker
Nov 1, 1989·Molecular and Biochemical Parasitology·I B KingstonD Cooper
Jun 1, 1993·Immunology and Cell Biology·H S Rothenfluh, E J Steele
Apr 1, 1995·Immunology and Cell Biology·H S Rothenfluh
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·U KrawinkelK Rajewsky
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Anderson, I B Kingston
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S RudikoffM Heller
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R I NearM L Gefter
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J W MorinS Beychok
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P P ChenD A Carson
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P P ChenD A Carson
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·M NeiT Sitnikova
Nov 1, 1983·The Journal of Experimental Medicine·S RudikoffM Potter
Mar 1, 1984·The Journal of Experimental Medicine·S H Clarke, S Rudikoff
Oct 1, 1988·The Journal of Experimental Medicine·S E FergusonB A Osborne
Dec 1, 1991·The Journal of Experimental Medicine·A Manheimer-LoryB Diamond
Jul 1, 1992·The Journal of Experimental Medicine·A Manheimer-LoryB Diamond
Dec 1, 1994·AIDS Research and Human Retroviruses·E M van der DonkR W van der Heijden
Jun 11, 1984·Nucleic Acids Research·C J StoeckertS M Weissman
Jul 11, 1984·Nucleic Acids Research·H R JaenichenH G Zachau
Jul 11, 1984·Nucleic Acids Research·B StraubingerH G Zachau
Feb 10, 1984·Nucleic Acids Research·J C Schimenti, C H Duncan
Sep 25, 1985·Nucleic Acids Research·H G KlobeckH G Zachau
Sep 25, 1985·Nucleic Acids Research·H G KlobeckH G Zachau
May 12, 1986·Nucleic Acids Research·U KrawinkelA L Bothwell
May 12, 1986·Nucleic Acids Research·L Weir, P Leder
May 25, 1994·Nucleic Acids Research·D A RamsdenG E Wu
May 1, 1990·Scandinavian Journal of Immunology·P P Chen, P M Yang

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