PMID: 3214273Jan 1, 1988Paper

Evolution of influenza polymerase: nucleotide sequence of the PB2 gene of A/Chile/1/83 (H1 N1)

Archives of Virology
E SchreierS Dittmann

Abstract

The complete nucleotide sequence of the PB2 gene of influenza virus A/Chile/1/83 (H1 N1) is presented. Sequence comparison between A/Chile PB2 protein and the known PB2 sequences of the influenza strains A/WSN/33 (H1 N1), A/PR/8/34 (H1 N1), A/NT/60/68 (H3 N2), A/Kiev/59/79 (H1 N1), A/FPV/Rostock/34 (H7 N1), and B/Ann Arbor/1/66 indicates extensive amino acid homology for the influenza A virus PB2 proteins. Small clusters of basic amino acids are conserved in all PB2 proteins including the influenza B PB2 protein which has only 39% sequence homology overall to the PB2 polypeptides of type A influenza viruses. The evolutionary rate of 5.7 x 10(-3) nucleotide substitutions per site per year and 0.25% amino acid changes per year between the A/Chile/1/83 and A/NT/60/68 PB2 appears to be higher than that calculated earlier for A/NT, A/PR/8 and A/WSN. An unusually high degree of sequence change between A/Chile/1/83 and A/Kiev/59/79 PB2 polymerase was revealed and this is discussed in terms of its probable origin.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J F Young, P Palese
Jun 24, 1977·Science·K F ShortridgeC H Campbell
Jul 11, 1989·Nucleic Acids Research·E SchreierS Michel
May 1, 1983·The Biochemical Journal·J W McCauley, B W Mahy
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Jan 15, 1982·Virology·D BlaasE Kuechler
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·I UlmanenR M Krug

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