PMID: 7514364Apr 1, 1994Paper

Evolution of marsupial and other vertebrate thyroxine-binding plasma proteins

The American Journal of Physiology
S J RichardsonG Schreiber

Abstract

Binding of radioactive thyroxine to proteins in the plasma of vertebrates was studied by electrophoresis followed by autoradiography. Albumin was found to be a thyroxine carrier in the blood of all studied fish, amphibians, reptiles, monotremes, marsupials, eutherians (placental mammals), and birds. Thyroxine binding to transthyretin was detected in the blood of eutherians, diprotodont marsupials, and birds, but not in blood from fish, toads, reptiles, monotremes, and Australian polyprotodont marsupials. Globulins binding thyroxine were only observed in the plasma of some mammals. Apparently, albumin is the phylogenetically oldest thyroxine carrier in vertebrate blood. Transthyretin gene expression in the liver developed in parallel, and independently, in the evolutionary lineages leading to eutherians, to diprotodont marsupials, and to birds. In contrast, high transthyretin mRNA levels, strong synthesis, and secretion of transthyretin in choroid plexus from reptiles and birds indicate that transthyretin gene expression in the choroid plexus evolved much earlier than in the liver, probably at the stage of the stem reptiles. NH2-terminal sequence analysis suggests a change of transthyretin pre-mRNA splicing during evolution.

Citations

Sep 4, 2009·The FEBS Journal·P Prapunpoj, L Leelawatwattana
Aug 24, 2019·Frontiers in Endocrinology·Sarah A RabahSamantha J Richardson
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P PrapunpojG Schreiber
Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Porntip PrapunpojGerhard Schreiber
May 10, 2017·Frontiers in Neuroscience·Stewart C Nicol
Jan 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Samantha J RichardsonMarilyn B Renfree
Jul 16, 2008·Molecular and Cellular Endocrinology·Isabel MorgadoDeborah M Power
Jan 16, 2007·General and Comparative Endocrinology·Richard G ManzonLori A Manzon

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