Evolution of metazoan cell junction proteins: the scaffold protein MAGI and the transmembrane receptor tetraspanin in the demosponge Suberites domuncula

Journal of Molecular Evolution
Teresa AdellWerner E G Müller

Abstract

Until recently the positioning of the sponges (phylum Porifera) within the metazoan systematics was hampered by the lack of molecular evidence for the existence of junctional structures in the surface cell layers. In this study two genes related to the tight junctions are characterized from the demosponge Suberites domuncula: tetraspanin (SDTM4SF), a cell surface receptor, and MAGI (SDMAGI), a MAGUK (membrane-associated guanylate kinase homologue) protein. Especially the MAGI protein is known in other metazoan animal phyla to exist exclusively in tight junctions. The characteristic domains of MAGI proteins (six PDZ domains, two WW domains, and a truncated guanylate kinase motif) are conserved in the sponge protein. The functional analysis of SDMAGI done by in situ hybridization shows its expression in the surface epithelial layers (exopinacoderm and endopinacoderm). Northern blot studies reveal that expression of SDMAGI and SDTM4SF increases after formation of the pinacoderm layer in the animals as well as in primmorphs. These results support earlier notions that sponges contain junctional structures. We conclude that sponges contain epithelia whose cells are organized by cell junctions.

References

Jan 1, 1975·Tissue & Cell·P W Ledger
Dec 11, 1991·Developmental Biology·M P SarrasB G Hudson
Oct 1, 1981·Cell Biology International Reports·M Pavans de Ceccatty
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Dec 1, 1994·Trends in Biochemical Sciences·P Bork, M Sudol
Jan 1, 1996·Biology of the Cell·N BouteR Garrone
Jun 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C P PontingD J Blake
Feb 21, 1998·Current Biology : CB·R Ranganathan, E M Ross
Feb 12, 1998·The Journal of Biological Chemistry·I DobrosotskayaG L James
Apr 29, 1998·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·J Nath, K L Johnson
Jul 2, 1998·Molecular and Cellular Neurosciences·J D WoodC A Ross
Aug 26, 1998·Biochimica Et Biophysica Acta·S C ToddS Levy
Mar 19, 1999·Proceedings. Biological Sciences·J SchützeW E Müller
Jul 27, 1999·Current Biology : CB·C YeamanW J Nelson
Feb 22, 2000·The Journal of Biological Chemistry·H ShojiH Sugino
Mar 25, 2000·Science·M D AdamsJ C Venter
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·X WuY E Whang
Apr 25, 2000·Biochemical and Biophysical Research Communications·I Y Dobrosotskaya, G L James
Sep 1, 2000·Seminars in Cell & Developmental Biology·L González-MariscalA Avila-Flores
Sep 12, 2000·Current Opinion in Genetics & Development·E Knust
Oct 6, 2000·Journal of Experimental Marine Biology and Ecology·J A Pechenik, S Lewis
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H C SchröderW E Müller
Mar 30, 2001·Molecular Phylogenetics and Evolution·K Klitgaard Nielsen, P Arctander
Jun 22, 2001·The Psychiatric Clinics of North America·S Nielsen
Jun 26, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·W E Müller
Nov 22, 2001·Journal of Endodontics·C J Nielsen
Apr 24, 2002·Experimental Cell Research·Richard P LauraLaurence A Lasky
Dec 12, 2002·Progress in Biophysics and Molecular Biology·L González-MariscalB E Jaramillo

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Citations

Feb 3, 2005·Nature Reviews. Immunology·Shoshana Levy, Tsipi Shoham
Aug 1, 2009·Integrative and Comparative Biology·Sally P LeysEmily D M Adams
Apr 3, 2010·BMC Evolutionary Biology·Alex de MendozaIñaki Ruiz-Trillo
Aug 7, 2007·BMC Evolutionary Biology·Aartjan J W te VelthuisChristoph P Bagowski
Oct 18, 2013·International Journal of Molecular Sciences·Bharat Bhusan PatnaikYeon Soo Han
Oct 30, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Sima JonusaiteScott P Kelly
Nov 8, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Sally P Leys, Ana Riesgo
Jun 30, 2006·Seminars in Cell & Developmental Biology·Werner E G Müller
Apr 17, 2015·In Vitro Cellular & Developmental Biology. Animal·Carla Huete-StaufferCarlo Cerrano
Nov 21, 2017·PLoS Neglected Tropical Diseases·Erick O AwuocheSerap Aksoy
Jun 24, 2005·Nature·Helen Pilcher
Sep 10, 2009·Nature Reviews. Neuroscience·Tomás J Ryan, Seth G N Grant
Jul 19, 2005·Physiology·Shoshana Levy, Tsipi Shoham
May 16, 2020·Frontiers in Cell and Developmental Biology·Guerric P B Samson, Daniel F Legler
Aug 6, 2020·Frontiers in Cell and Developmental Biology·Victoria D BaliseJennifer M Gillette
Jan 11, 2008·Molecular Biology and Evolution·Iñaki Ruiz-TrilloB Franz Lang

❮ Previous
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