Evolution of neuropsychological changes after partial callosotomy in intractable epilepsy

Epilepsy Research
L ProvincialiF Rychlicki

Abstract

Early neuropsychological changes following partial anterior callosotomy were evaluated in 15 patients with epilepsy (10 secondary generalized and 5 Lennox-Gastaut syndromes) by comparing their performances 1 month before surgery and then 15-20 and 90-100 days postoperatively without modifying the anticonvulsant treatment. The following neuropsychological and motor functions were tested: memory, attention, visuo-motor ability, posture, motor dexterity, language, praxis and gnosis. Social behaviour was also investigated. The main results are as follows: (i) most cognitive functions showed no significant variation; (ii) motor organization was still slightly impaired at the second check-up after the surgery; (iii) improvements in social behaviour and posture were frequently observed at the final evaluation. The analysis of individual cases highlights the influence of the extent of commissurotomy, lesions related to the surgical procedure and preoperative brain damage in determining the post-surgical profile. On this basis, the short-term neuropsychological cost of partial callosotomy appears to be low and seems to depend mostly on surgical parameters and brain conditions before the operation.

References

Mar 1, 1979·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·S J Dimond
Aug 1, 1977·Neurology·D H WilsonC Culver
Jul 1, 1978·Neurology·D H WilsonM Gazzaniga
Dec 1, 1978·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·S Dimond
Dec 1, 1978·Epilepsia·C B Dodrill
Mar 1, 1977·Brain : a Journal of Neurology·J E LedouxM S Gazzaniga
Jun 1, 1976·Brain : a Journal of Neurology·S J Dimond
Jan 1, 1988·Neurology·S S SpencerR H Mattson
Dec 1, 1987·Italian Journal of Neurological Sciences·I PapoF Rychlicki
Jan 1, 1987·Applied Neurophysiology·E Garcia-Flores
Oct 1, 1987·Brain : a Journal of Neurology·J Sergent
Jan 1, 1985·Acta neurochirurgica·G OepenJ Gilsbach
Jun 1, 1974·Brain : a Journal of Neurology·D Zaidel, R W Sperry
Jan 1, 1971·Brain : a Journal of Neurology·H W GordonR W Sperry
Jun 1, 1965·Brain : a Journal of Neurology·M S GazzanigaR W Sperry
Mar 1, 1984·Brain : a Journal of Neurology·G Plourde, R W Sperry
Sep 1, 1983·Journal of Neurosurgery·N M SussmanM J O'Connor
Jan 1, 1980·Neuropsychologia·L Ellenberg, R W Sperry
May 1, 1954·Journal of Neurosurgery·J LE BEAU
Sep 20, 1947·Lancet·W E L G CLARK, W R RUSSELL

❮ Previous
Next ❯

Citations

Jan 17, 2004·Epilepsy & Behavior : E&B·Christoph Helmstaedter
Apr 8, 1998·Seizure : the Journal of the British Epilepsy Association·N Buchanan, M Fearnside
Mar 25, 2016·Seizure : the Journal of the British Epilepsy Association·Iris UnterbergerGerhard Bauer
Oct 17, 2012·Seizure : the Journal of the British Epilepsy Association·Guido LancmanTheodore H Schwartz
Oct 2, 2014·Epilepsy & Behavior : E&B·Claudia PassamontiMassimo Scerrati
Jul 6, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D Schmidt, B Bourgeois

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.