Evolution of pathogen virulence across space during an epidemic

The American Naturalist
Erik E OsnasAndrew P Dobson


We explore pathogen virulence evolution during the spatial expansion of an infectious disease epidemic in the presence of a novel host movement trade-off, using a simple, spatially explicit mathematical model. This work is motivated by empirical observations of the Mycoplasma gallisepticum invasion into North American house finch (Haemorhous mexicanus) populations; however, our results likely have important applications to other emerging infectious diseases in mobile hosts. We assume that infection reduces host movement and survival and that across pathogen strains the severity of these reductions increases with pathogen infectiousness. Assuming these trade-offs between pathogen virulence (host mortality), pathogen transmission, and host movement, we find that pathogen virulence levels near the epidemic front (that maximize wave speed) are lower than those that have a short-term growth rate advantage or that ultimately prevail (i.e., are evolutionarily stable) near the epicenter and where infection becomes endemic (i.e., that maximize the pathogen basic reproductive ratio). We predict that, under these trade-offs, less virulent pathogen strains will dominate the periphery of an epidemic and that more virulent strains will incre...Continue Reading


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Sep 30, 2015·Evolution; International Journal of Organic Evolution·Quentin GrietteSylvain Gandon
Nov 1, 2016·Proceedings. Biological Sciences·S Lion, Sylvain Gandon
Feb 6, 2017·Trends in Parasitology·A A Dhondt, Andrew P Dobson
May 21, 2017·Applied and Environmental Microbiology·Xavier Fernández-AguilarJorge Ramón López-Olvera
Jan 24, 2020·Expert Review of Vaccines·Andrew S FliesRuth J Pye
Oct 5, 2018·Journal of the Royal Society, Interface·Todd L ParsonsSylvain Gandon


Mar 1, 1996·The Quarterly Review of Biology·S A Frank
Mar 8, 2000·Journal of Theoretical Biology·Y Haraguchi, A Sasaki
Jun 1, 1951·Biometrika·J G SKELLAM
May 4, 2004·The American Naturalist·Troy Day, Stephen R Proulx
May 8, 2007·Ecological Applications : a Publication of the Ecological Society of America·Christopher S JennelleJuan Carlos Senar
Aug 21, 2009·The American Naturalist·Susanna M Messinger, Annette Ostling
Oct 30, 2009·Journal of the Royal Society, Interface·Benjamin M BolkerDharmini Shah
Oct 16, 2010·Journal of Evolutionary Biology·J M J TravisO J Burton
Jan 22, 2011·Science·Sonia AltizerBarbara A Han
Apr 23, 2014·Journal of Evolutionary Biology·P D WilliamsA A Dhondt

Related Concepts

Pathogenic Organism
Spatial Distribution
Carpodacus mexicanus
Theoretical Study
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