Evolution of pathogen virulence: the role of variation in host phenotype

Proceedings. Biological Sciences
K S Pfennig

Abstract

Selection on pathogens tends to favour the evolution of growth and reproductive rates and a concomitant level of virulence (damage done to the host) that maximizes pathogen fitness. Yet, because hosts often pose varying selective environments to pathogens, one level of virulence may not be appropriate for all host types. Indeed, if a level of virulence confers high fitness to the pathogen in one host phenotype but low fitness in another host phenotype, alternative virulence strategies may be maintained in the pathogen population. Such strategies can occur either as polymorphism, where different strains of pathogen evolve specialized virulence strategies in different host phenotypes or as polyphenism, where pathogens facultatively express alternative virulence strategies depending on host phenotype. Polymorphism potentially leads to specialist pathogens capable of infecting a limited range of host phenotypes, whereas polyphenism potentially leads to generalist pathogens capable of infecting a wider range of hosts. Evaluating how variation among hosts affects virulence evolution can provide insight into pathogen diversity and is critical in determining how host pathogen interactions affect the phenotypic evolution of both hosts a...Continue Reading

References

Dec 22, 1992·Proceedings. Biological Sciences·S A Frank
Oct 22, 1983·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R M May, R M Anderson
Feb 7, 1983·Journal of Theoretical Biology·H J Bremermann, J Pickering
Aug 22, 1995·Proceedings. Biological Sciences·R M May, M A Nowak
Jun 21, 1995·Journal of Theoretical Biology·M Lipsitch, M A Nowak
Nov 22, 1994·Proceedings. Biological Sciences·S A Frank
Jun 22, 1994·Proceedings. Biological Sciences·D H Clayton, D M Tompkins
Jan 22, 1994·Proceedings. Biological Sciences·M A Nowak, R M May
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·S GuptaK P Day
Jan 1, 1994·Annals of Neurology·M E Weksler
Sep 22, 1995·Proceedings. Biological Sciences·S Gupta, A V Hill
Jun 22, 1996·Proceedings. Biological Sciences·S BonhoefferD Ebert
Mar 1, 1996·The Quarterly Review of Biology·S A Frank
Jan 1, 1997·Trends in Microbiology·M Lipsitch, E R Moxon
Jan 1, 1997·International Journal for Parasitology·C Combes
Jan 1, 1997·Parasitology·R Antia, M Lipsitch
Nov 20, 1998·Science·D Ebert
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·S VerhulstH K Parmentier
Aug 24, 1999·Immunological Investigations·J L RosenS M Viselli
Nov 11, 1999·Parasitology Today·R Poulin, C Combes
Jun 23, 2000·Nature·C M Lively, M F Dybdahl
Aug 11, 2000·Evolution; International Journal of Organic Evolution·R R RegoesS Bonhoeffer
Mar 1, 1996·Parasitology Today·D Ebert, E A Herre
Jan 1, 1994·Parasitology Today·P Schmid-Hempel, J C Koella
Feb 1, 1996·Trends in Ecology & Evolution·D Ebert, W D Hamilton
Oct 1, 1998·Age·E D Bernstein, D M Murasko
Jun 1, 1991·Evolution; International Journal of Organic Evolution·J J BullW R Rice
Dec 1, 1989·Evolution; International Journal of Organic Evolution·Curtis M Lively
Oct 1, 1993·Evolution; International Journal of Organic Evolution·Marc TatarJames W Vaupel
Aug 1, 1995·Evolution; International Journal of Organic Evolution·Marc LipsitchMartin A Nowak
Oct 1, 1996·Evolution; International Journal of Organic Evolution·Marc LipsitchMartin A Nowak
Jun 1, 1999·Evolution; International Journal of Organic Evolution·Robert J Knell
Jun 1, 1999·Evolution; International Journal of Organic Evolution·Margaret J Mackinnon, Andrew F Read
Apr 1, 1998·Evolution; International Journal of Organic Evolution·Louise H TaylorAndrew F Read
Oct 1, 1994·Evolution; International Journal of Organic Evolution·J J Bull

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Citations

Oct 24, 2008·Phytopathology·Soledad SacristánFernando García-Arenal
Aug 6, 2004·Proceedings. Biological Sciences·Robert M SeymourKenth Gustafsson
Feb 21, 2002·Infection and Immunity·Kent B MartySteven R Blanke
May 4, 2004·The American Naturalist·Troy Day, Stephen R Proulx
Sep 26, 2013·Evolutionary Applications·Mónica BetancourtFernando García-Arenal
Jul 28, 2012·Evolution; International Journal of Organic Evolution·Barbara Boldin, Eva Kisdi
Apr 22, 2010·The New Phytologist·Susan E MeyerSuzette Clement
Jan 13, 2006·Behavioural Processes·Fleur PontonFrédéric Thomas
Mar 13, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Miguel Moreno-GarcíaHumberto Lanz-Mendoza
May 14, 2016·BMC Evolutionary Biology·Celeste C LindeRod Peakall
Jul 15, 2016·Proceedings. Biological Sciences·T Alex PerkinsGonzalo M Vazquez-Prokopec
Mar 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rashad EletrebyH Vincent Poor

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