To assess the prenatal ultrasound detection rates (DR) of neural tube defects (NTDs) and its evolution over the 1992 to 2006 period in the pregnant population of the city of Barcelona. Data on the population-based register of birth defects were used to assess the evolution of the prenatal DR for isolated NTD, including anencephaly, spina bifida and encephalocele by trimester of gestation. In the register, 127 isolated NTD cases, including 71 anencephalic fetuses, 49 spina bifidas and 7 encephaloceles were noted. Overall, prenatal ultrasound DR for isolated NTD was 94%. All fetuses with anencephaly or encephalocele were prenatally detected (100% DR), whereas DR for spina bifida was 84%, with no apparent variation over the observation period. An important increase in first trimester DRs was observed for anencephaly, rising from 16% in the first years of the study (1992-1996) to 71% in the last years (2002-2006). A high DR (94%) for isolated NTD was observed in the city of Barcelona. The single significant change across the study period was an increase in the first trimester DR for anencephaly (from 16% to 71%).
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Increasing detection rates of birth defects by prenatal ultrasound leading to apparent increasing prevalence. Lessons learned from the population-based registry of birth defects of Barcelona
The impact of prenatal diagnosis on neural tube defect (NTD) pregnancy versus birth incidence in British Columbia.
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Comparison of the INTERGROWTH-21st, National Institute of Child Health and Human Development, and WHO fetal growth standards
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Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden
Autopsy Findings of Central Nervous System Anomalies in Intact Fetuses Following Termination of Pregnancy After Prenatal Ultrasound Diagnosis
Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.