Evolution of rational vaccine designs for genital herpes immunotherapy

Current Opinion in Virology
Johanna Katharina Kaufmann, Jessica B Flechtner

Abstract

Immunotherapeutic vaccines have emerged as a novel treatment modality for genital herpes, a sexually transmitted disease mainly caused by herpes simplex virus type 2. The approaches to identify potential vaccine antigens have evolved from classic virus attenuation and characterization of antibody and T cell responses in exposed, but seronegative individuals, to systematic screens for novel T cell antigens. Combined with implementation of novel vaccine concepts revolving around immune evasion and local recruitment of immune effectors, the development of a safe and effective therapeutic vaccine is within reach. Here, we describe the vaccine approaches that currently show promise at clinical and pre-clinical stages and link them to the evolving scientific strategies that led to their identification.

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Citations

Aug 17, 2016·Nanomedicine·Tejabhiram Yadavalli, Deepak Shukla
Sep 24, 2019·Human Vaccines & Immunotherapeutics· SunitaPratyoosh Shukla
Oct 27, 2020·Frontiers in Immunology·Morgan BrisseHinh Ly

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