PMID: 2504927Jun 1, 1989Paper

Evolution of RNA genomes: does the high mutation rate necessitate high rate of evolution of viral proteins?

Journal of Molecular Evolution
E V Koonin, A E Gorbalenya

Abstract

RNA genomes have been shown to mutate much more frequently than DNA genomes. It is generally assumed that this results in rapid evolution of RNA viral proteins. Here, an alternative hypothesis is proposed that close cooperation between positive-strand RNA viral proteins and those of the host cells required their coevolution, resulting in similar amino acid substitution rates. Constraints on compatibility with cellular proteins should determine, at any time, the covarion sets in RNA viral proteins. These ideas may be helpful in rationalizing the accumulating data on significant sequence similarities between proteins of positive-strand RNA viruses infecting evolutionarily distant hosts as well as between viral and cellular proteins.

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Citations

Feb 11, 2005·Applied Microbiology and Biotechnology·F R Schmidt
Aug 1, 1991·Current Opinion in Immunology·E D Kilbourne
Nov 11, 2008·Nature Reviews. Microbiology·Eugene V KooninValerian V Dolja
Apr 1, 1993·In Vitro Cellular & Developmental Biology. Animal·H Koblet
Jan 1, 1993·Critical Reviews in Biochemistry and Molecular Biology·E V Koonin, V V Dolja
Mar 1, 2006·Virus Research·Alexander E GorbalenyaEric J Snijder
Apr 5, 2016·Scientific Reports·Masayuki IshitsukaJose C Nacher
Aug 20, 2019·The Journal of General Virology·Beata KomorowskaSantiago F Elena
Mar 7, 2020·Microbiology and Molecular Biology Reviews : MMBR·Eugene V KooninJens H Kuhn
Dec 7, 2018·Nature Reviews. Microbiology·Peter SimmondsAris Katzourakis

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