Evolution of serum and intra-graft donor-specific anti-HLA antibodies in a patient with two consecutive liver transplantations

Transplant Immunology
Martine Neau-CransacJean-Luc Taupin

Abstract

The current literature suggests that anti-HLA donor-specific antibodies (DSA) may have deleterious effects on liver grafts but there is no proof that they are directly involved in the graft lesions. We report the case of a donor HLA-sensitized patient who needed a second graft 6 months after the first transplantation owing to a progressive cholestatic disease that we could finally attribute to antibody-mediated rejection (AMR). We describe the longitudinal evolution of graft function, tissue histology, serum DSA and, for the first time, intra-graft DSA after elution from biopsies.

References

Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S FengR M Merion
Apr 3, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marcela Castillo-RamaEstela Paz-Artal
Feb 24, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A I MusatM R Lucey
Mar 31, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W DarS J Knechtle
Mar 17, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T TanerJ K Heimbach
Jun 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H KanekuP I Terasaki
Oct 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T BacheletJ-L Taupin
Jan 3, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jacqueline G O'LearyGöran B Klintmalm
Mar 4, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J G O'LearyG B Klintmalm
Jul 22, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jacqueline G O'LearyAnthony J Demetris

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Citations

Feb 27, 2016·Current Opinion in Organ Transplantation·Peter T W KimJacqueline G O'Leary
Jul 28, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jonathan VisentinJean-Luc Taupin
Feb 21, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J LevitskyA R Tambur
Aug 24, 2019·The European Respiratory Journal·Annelore SacreasUNKNOWN and the Leuven Lung Transplant Group
Oct 15, 2020·HLA : Immune Response Genetics·Jonathan VisentinJean-Luc Taupin

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