Evolution of serum atherogenic risk in liver transplant recipients: Role of lipoproteins and metabolic and inflammatory markers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Ravi ChhatralaM Shadab Siddiqui

Abstract

Although cardiovascular disease (CVD) is the leading cause of long-term mortality in liver transplant recipients (LTRs), the role of recently identified biomarkers of CVD risk in liver transplantation is unknown. We aimed to evaluate an extensive CVD risk profile in LTRs. Markers of CVD risk in 65 LTRs with no known history of diabetes mellitus (DM), dyslipidemia, or ischemic heart disease were compared to age-, sex-, and body mass index (BMI)-matched controls with no chronic medical disease. LTRs on corticosteroids or those with graft cirrhosis (GC) were excluded. The effect of calcineurin inhibitors on the CVD risk profile was separately analyzed in LTRs receiving either tacrolimus (Tac) or cyclosporine A (CsA). To evaluate the impact of GC, a comparison was made between LTRs with and without GC. Non-DM LTRs were matched to controls with respect to age, sex, and BMI. LTRs had similar serum high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and total cholesterol in comparison with BMI-matched controls. Proatherogenic small-dense (sd) LDL-C (33.6 ± 14 versus 25.9 ± 9.9 mg/dL; P < 0.001) and %sdLDL-C (30% ± 10% versus 26.4% ± 9%; P = 0.02) were significantly higher in LTRs. In comparison w...Continue Reading

References

Sep 12, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J PruthiT L Fong
Mar 30, 2002·Transplantation·Simon D JohnstonJames Neuberger
Sep 18, 2002·Journal of Lipid Research·Kaspar K Berneis, Ronald M Krauss
Sep 10, 2003·Transplantation Proceedings·F MazuelosV Cuervas-Mons
Jul 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Christian V HulzebosHenkjan J Verkade
Aug 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marie LaryeaKevork M Peltekian
Jun 16, 2009·Gastroenterology·Anna KotronenHannele Yki-Järvinen
May 22, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K D S WattM R Charlton
Jun 10, 2011·Clinical Pharmacology and Therapeutics·C HerderW Koenig
Jan 24, 2012·Clinics and Research in Hepatology and Gastroenterology·Mehdi RasouliHanieh Tahmouri
Jul 24, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Surabhi MadhwalMarco A Costa
Apr 3, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kymberly D WattMichael R Charlton
Jul 9, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·M Shadab SiddiquiRichard K Sterling
Oct 15, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mohamed S SiddiquiArun J Sanyal

❮ Previous
Next ❯

Citations

Oct 16, 2015·Nature Reviews. Gastroenterology & Hepatology·Kymberly D Watt
Apr 4, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Steven Van LaeckeWim Van Biesen
Mar 25, 2016·World Journal of Transplantation·Arnav Agarwal, G V Ramesh Prasad
May 4, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomomi Kogiso, Katsutoshi Tokushige
Oct 20, 2018·Transplantation·Giacomo GermaniKymberly D Watt
Jan 24, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mohammad Bilal SiddiquiMohammad Shadab Siddiqui
Oct 15, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas G Cotter, Michael Charlton
Sep 27, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mohammad Bilal Siddiqui, Mohammad Shadab Siddiqui
Aug 1, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael O IdowuM Shadab Siddiqui
Apr 5, 2019·Transplantation·Mohammad Bilal SiddiquiMohammad Shadab Siddiqui
Nov 3, 2016·Current Opinion in Lipidology·Maaike Kockx, Leonard Kritharides
Aug 18, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Rahima A Bhanji, Kymberly D Watt
Apr 23, 2017·Current Treatment Options in Gastroenterology·Brian C Davis, M Shadab Siddiqui
Jul 26, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Samarth S PatelMohammad Shadab Siddiqui
Sep 29, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Takeo ToshimaMasaki Mori
Feb 9, 2020·Gastroenterology Clinics of North America·Anchalia Chandrakumaran, Mohammad Shadab Siddiqui
Dec 28, 2018·Transplantation Proceedings·L M C LinharesL A C D'Albuquerque
Apr 11, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Taseen Syed, Mohammad S Siddiqui

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

© 2021 Meta ULC. All rights reserved