Evolution of shear stress, protein expression, and vessel area in an animal model of arterial dilatation in hemodialysis grafts.

Journal of Vascular and Interventional Radiology : JVIR
Sanjay MisraDebabrata Mukhopadyay

Abstract

To evaluate the wall shear stress, protein expression of matrix metalloproteinase (MMP)-2 and MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 and TIMP-2, and vessel area over time in a porcine model for polytetrafluoroethylene (PTFE) hemodialysis grafts. In 21 pigs, subtotal renal infarction was created, and 28 days later, a PTFE graft was placed to connect the carotid artery to the ipsilateral jugular vein. Phase-contrast magnetic resonance imaging was used to measure blood flow and vessel area at 1, 3, 7, and 14 days after graft placement. Wall shear stress was estimated from the law of Poiseuille. Animals were killed at day 3 (n = 7), day 7 (n = 7), and day 14 (n = 7) and expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 were determined at the grafted and control arteries. The mean wall shear stress of the grafted artery was higher than in the control artery at all time points (P < .05). It peaked by day 3 and decreased by days 7-14 as the vessel area nearly doubled. By days 7-14, there was a significant increase in active MMP-2 followed by a significant increase in pro-MMP-9 and active MMP-9 by day 14 (P < .05, grafted artery vs control). TIMP-1 expression peaked by day 7 and then decreased, whereas TIMP-2 expr...Continue Reading

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Nov 26, 2008·Journal of Vascular and Interventional Radiology : JVIR·Sanjay MisraDebabrata Mukhopadhyay

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Citations

Oct 28, 2011·Journal of Vascular and Interventional Radiology : JVIR·Binxia YangSanjay Misra
Oct 8, 2013·Journal of Vascular Surgery·Christopher D OwensMichael S Conte
Apr 13, 2017·Open Medicine·Hee-Kyung JinSung-Hyoun Cho
Oct 14, 2014·The Open Urology & Nephrology Journal·Michelle K FittsYan-Ting Shiu
Dec 10, 2019·American Journal of Physiology. Renal Physiology·Chuanqi CaiSanjay Misra

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