Abstract
There is an increased prevalence of subclinical hypothyroidism (SCH) in patients with obesity. It is unclear if this biochemical abnormality may be a secondary phenomenon of obesity or a real hypothyroid state. A retrospective study of all the morbidly obese patients undergoing laparoscopic sleeve gastrectomy as bariatric procedure between October 2007 and November 2012 was performed. Weight loss, body mass index (BMI) and excess weight loss, baseline glucose, lipid profiles, and TSH levels were obtained before operation and postoperative determinations at 3, 6, and 12 months after surgery. Sixty patients were included. Prevalence of subclinical hypothyroidism was 16.7% preoperatively, 10% at 3 months, 3.3% at 6 months, and 1.7% at 12 months. A significant correlation could be established between TSH decrease and weight loss at 12 months (Pearson 0.603; p = 0.007). TSH decrease showed a significant correlation with glucose and glycated hemoglobin decrease from 6th month onwards. Referring to lipid profile, an association of TSH decrease with total cholesterol, LDL cholesterol, or HDL cholesterol could not be determined. A significant association between TSH decrease and triglycerides and cardiovascular risk index triglycerides/...Continue Reading
References
Nov 14, 1997·Circulation·J M GazianoJ E Buring
Jun 1, 2000·Metabolism: Clinical and Experimental·H VierhapperP Grösser
Jun 1, 2001·Acta Clinica Belgica·S ProcesJ E Donckier
Dec 3, 2002·Annals of Internal Medicine·Bernadette BiondiSerafino Fazio
Aug 2, 2003·Trends in Endocrinology and Metabolism : TEM·Mark Vanderpump
Mar 11, 2005·Endocrine Journal·Alpaslan TuzcuKemal Gunes
Sep 29, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A NyrnesJ Sundsfjord
Jun 6, 2007·Clinical Endocrinology·G De PergolaR Giorgino
Nov 21, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Silas ChikunguwoPhilip Schauer
Mar 26, 2008·Archives of Internal Medicine·Caroline S FoxRamachandran S Vasan
Nov 18, 2008·Annals of Nutrition & Metabolism·J C GalofréJ Salvador
Jun 1, 2010·São Paulo Medical Journal = Revista Paulista De Medicina·Rodrigo Diaz-OlmosIsabela Martins Benseñor
Jun 11, 2010·The Journal of Clinical Endocrinology and Metabolism·Paolo MarzulloAntonio Liuzzi
Feb 15, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Cem CelikMurat Yılmaz
Jul 4, 2012·Endocrine Research·Soumaya KouidhiAmel Benammar Elgaaied
Mar 26, 2013·Endocrine·Mario RotondiLuca Chiovato
Apr 12, 2013·Endocrine Reviews·Ferdinand Roelfsema, Johannes D Veldhuis
Citations
Apr 15, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Ignace M C JanssenHans de Boer
Aug 26, 2015·Scientific Reports·Yongfeng SongJiajun Zhao
Apr 8, 2015·International Journal of Clinical Practice·J V Hennessey, R Espaillat
Oct 5, 2016·PloS One·Kun LiPin Zhang
Apr 6, 2017·Lipids in Health and Disease·Xingchun WangShen Qu
Nov 4, 2017·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Vitish SinglaSamagra Agarwal
Oct 19, 2017·Obesity Surgery·Bingsheng GuanCunchuan Wang
Sep 24, 2014·Journal of Bone Metabolism·Ki-Choul KimKyung-Hoi Koo
Jul 12, 2019·Obesity Surgery·Cuiling ZhuShen Qu
Nov 23, 2019·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Tamer N AbdelbakiMaha Bondok
Mar 24, 2020·Obesity·Jeffrey I MechanickChristopher D Still
Sep 17, 2014·Current Opinion in Anaesthesiology·Hairil R Abdullah, Frances Chung
Oct 20, 2018·Frontiers in Physiology·Bin WangJin-An Zhang
May 18, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·João Sérgio NevesUNKNOWN AMTCO Group
Dec 19, 2019·Obesity Surgery·Dina S AlmunifMohammed A Batais
Nov 5, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey I MechanickChristopher D Still
Jan 10, 2020·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Jeffrey I MechanickChristopher D Still
Jun 28, 2021·World Journal of Surgery·Mohamed AbdAlla SalmanHaitham S E Omar