Evolution of subclinical hypothyroidism and its relation with glucose and triglycerides levels in morbidly obese patients after undergoing sleeve gastrectomy as bariatric procedure

Obesity Surgery
Jaime Ruiz-TovarRafael Calpena

Abstract

There is an increased prevalence of subclinical hypothyroidism (SCH) in patients with obesity. It is unclear if this biochemical abnormality may be a secondary phenomenon of obesity or a real hypothyroid state. A retrospective study of all the morbidly obese patients undergoing laparoscopic sleeve gastrectomy as bariatric procedure between October 2007 and November 2012 was performed. Weight loss, body mass index (BMI) and excess weight loss, baseline glucose, lipid profiles, and TSH levels were obtained before operation and postoperative determinations at 3, 6, and 12 months after surgery. Sixty patients were included. Prevalence of subclinical hypothyroidism was 16.7% preoperatively, 10% at 3 months, 3.3% at 6 months, and 1.7% at 12 months. A significant correlation could be established between TSH decrease and weight loss at 12 months (Pearson 0.603; p = 0.007). TSH decrease showed a significant correlation with glucose and glycated hemoglobin decrease from 6th month onwards. Referring to lipid profile, an association of TSH decrease with total cholesterol, LDL cholesterol, or HDL cholesterol could not be determined. A significant association between TSH decrease and triglycerides and cardiovascular risk index triglycerides/...Continue Reading

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Citations

Apr 15, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Ignace M C JanssenHans de Boer
Apr 8, 2015·International Journal of Clinical Practice·J V Hennessey, R Espaillat
Nov 4, 2017·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Vitish SinglaSamagra Agarwal
Nov 23, 2019·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Tamer N AbdelbakiMaha Bondok
Sep 17, 2014·Current Opinion in Anaesthesiology·Hairil R Abdullah, Frances Chung
May 18, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·João Sérgio NevesUNKNOWN AMTCO Group

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