Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes

Journal of Natural Products
Oier Aizpurua-OlaizolaAresatz Usobiaga

Abstract

The evolution of major cannabinoids and terpenes during the growth of Cannabis sativa plants was studied. In this work, seven different plants were selected: three each from chemotypes I and III and one from chemotype II. Fifty clones of each mother plant were grown indoors under controlled conditions. Every week, three plants from each variety were cut and dried, and the leaves and flowers were analyzed separately. Eight major cannabinoids were analyzed via HPLC-DAD, and 28 terpenes were quantified using GC-FID and verified via GC-MS. The chemotypes of the plants, as defined by the tetrahydrocannabinolic acid/cannabidiolic acid (THCA/CBDA) ratio, were clear from the beginning and stable during growth. The concentrations of the major cannabinoids and terpenes were determined, and different patterns were found among the chemotypes. In particular, the plants from chemotypes II and III needed more time to reach peak production of THCA, CBDA, and monoterpenes. Differences in the cannabigerolic acid development among the different chemotypes and between monoterpene and sesquiterpene evolution patterns were also observed. Plants of different chemotypes were clearly differentiated by their terpene content, and characteristic terpenes ...Continue Reading

References

Feb 1, 1995·Journal of Pain and Symptom Management·J E BealK V Shepard
Jan 12, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aminah JatoiBrad Christensen
May 16, 2002·Natural Product Reports·Paul M Dewick
Nov 5, 2002·Journal of Clinical Pharmacology·Raphael MechoulamRuth Gallily
Feb 15, 2003·Genetics·Etienne P M de MeijerGiuseppe Mandolino
Apr 29, 2003·The Journal of Clinical Psychiatry·Kirsten R Müller-VahlHinderk M Emrich
Oct 4, 2005·Life Sciences·Mahmoud A Elsohly, Desmond Slade
Dec 5, 2006·Molecular Pharmaceutics·Lisa M EubanksKim D Janda
Aug 23, 2007·Chemistry & Biodiversity·Ethan B Russo
Sep 11, 2007·British Journal of Pharmacology·V A Campbell, A Gowran
Dec 20, 2007·Expert Review of Neurotherapeutics·Daniela Parolaro, Paola Massi
Mar 21, 2008·The Journal of Pharmacology and Experimental Therapeutics·Luciano De PetrocellisVincenzo Di Marzo
Apr 12, 2008·The Journal of Pain : Official Journal of the American Pain Society·Barth WilseyScott Fishman
Feb 13, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H Wagner, G Ulrich-Merzenich
Feb 21, 2009·CNS Neuroscience & Therapeutics·Teresa IuvoneLuca Steardo
Sep 5, 2009·Trends in Pharmacological Sciences·Angelo A IzzoRaphael Mechoulam
Mar 24, 2011·British Journal of Clinical Pharmacology·Mary E Lynch, Fiona Campbell
Jul 14, 2011·British Journal of Pharmacology·Ethan B Russo
Jan 28, 2012·Recent Patents on CNS Drug Discovery·Onintza SagredoJavier Fernandez-Ruiz
May 5, 2012·Nature Reviews. Cancer·Guillermo VelascoManuel Guzmán
May 16, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jody Corey-BloomBen Gouaux
May 19, 2012·British Journal of Pharmacology·Luciano De PetrocellisVincenzo Di Marzo
Dec 15, 2012·The Journal of Pain : Official Journal of the American Pain Society·Barth WilseyHaylee Donaghe
May 21, 2013·The American Journal of Medicine·Elizabeth A PennerMurray A Mittleman
May 21, 2013·Addictive Behaviors·Celia J A MorganSunjeev K Kamboj
Aug 15, 2013·Neurochemistry International·Noriko Shinjyo, Vincenzo Di Marzo
Nov 19, 2013·Epilepsy & Behavior : E&B·Brenda E Porter, Catherine Jacobson
Oct 24, 2014·Analytical and Bioanalytical Chemistry·Oier Aizpurua-OlaizolaAresatz Usobiaga
Jun 21, 2015·Phytochemistry·Safwat A AhmedMahmoud A ElSohly

❮ Previous
Next ❯

Citations

Aug 25, 2016·Drug Discovery Today·Oier Aizpurua-OlaizolaAresatz Usobiaga
Sep 28, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Bruna Tassi BorilleRenata Pereira Limberger
Jan 26, 2017·Forensic Science International : Synergy·Laurence Dujourdy, Fabrice Besacier
Mar 30, 2017·PloS One·Judith K BoothJörg Bohlmann
Dec 19, 2017·Biotechnology Letters·Tomasz WróbelRyszard Słomski
Jul 24, 2018·PloS One·Richard D RichinsMary A O'Connell
Feb 23, 2019·Current Drug Research Reviews·Brienna N MeffertAdrienne J Heinz
Sep 22, 2017·Chemical Society Reviews·Tomáš Pluskal, Jing-Ke Weng
Oct 2, 2019·Journal of Psychosocial Nursing and Mental Health Services·Andrew Penn
Aug 31, 2019·The Plant Journal : for Cell and Molecular Biology·Samuel J LivingstonA Lacey Samuels
Feb 26, 2020·Substance Use & Misuse·Meghann WheelerHanadi Hamadi
Apr 26, 2020·Current Opinion in Supportive and Palliative Care·Howard MengHance Clarke
Aug 29, 2019·Journal of Psychosocial Nursing and Mental Health Services·Andrew Penn
Oct 18, 2019·Brain Injury : [BI]·David W LawrenceMark Bayley
Dec 12, 2019·Systematic Reviews·Misty PrattBrian Hutton
Apr 7, 2020·Cell Cycle·Olga Kovalchuk, Igor Kovalchuk
Jun 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marialuisa FormatoSeverina Pacifico
Jun 17, 2020·British Journal of Pain·Stephen Ph Alexander
Jul 14, 2017·Frontiers in Pharmacology·Paula MoralesNadine Jagerovic
Jul 7, 2017·Frontiers in Pharmacology·Rafael N RuggieroLezio S Bueno-Junior
May 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Radmila PavlovicAnnamaria Giorgi
Oct 17, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Federica PellatiStefania Benvenuti
Mar 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucia MarchettiDavide Bertelli
Mar 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luca GiupponiAnnamaria Giorgi
Jul 17, 2020·Antibiotics·John A KarasTony Velkov
Jun 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristina PrandiHinanit Koltai
Jun 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mara MandrioliTullia Gallina Toschi
Aug 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dvora NamdarHinanit Koltai
Apr 9, 2020·Frontiers in Microbiology·Dominique ComeauMartin Filion
Jan 3, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Anna-Maria SmolyakovaRobert B Laprairie
Jan 16, 2019·Current Addiction Reports·Aliya M LucatchTony P George
Apr 10, 2020·Frontiers in Pharmacology·David B FinlayMichelle Glass
Feb 6, 2018·PloS One·Avery N Gilbert, Joseph A DiVerdi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.