Evolution of the "drivers" of translational cancer epidemiology: analysis of funded grants and the literature

American Journal of Epidemiology
Tram Kim LamSheri D Schully

Abstract

Concurrently with a workshop sponsored by the National Cancer Institute, we identified key "drivers" for accelerating cancer epidemiology across the translational research continuum in the 21st century: emerging technologies, a multilevel approach, knowledge integration, and team science. To map the evolution of these "drivers" and translational phases (T0-T4) in the past decade, we analyzed cancer epidemiology grants funded by the National Cancer Institute and published literature for 2000, 2005, and 2010. For each year, we evaluated the aims of all new/competing grants and abstracts of randomly selected PubMed articles. Compared with grants based on a single institution, consortium-based grants were more likely to incorporate contemporary technologies (P = 0.012), engage in multilevel analyses (P = 0.010), and incorporate elements of knowledge integration (P = 0.036). Approximately 74% of analyzed grants and publications involved discovery (T0) or characterization (T1) research, suggesting a need for more translational (T2-T4) research. Our evaluation indicated limited research in 1) a multilevel approach that incorporates molecular, individual, social, and environmental determinants and 2) knowledge integration that evaluate...Continue Reading

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Citations

Mar 15, 2015·American Journal of Epidemiology·Robert A Hiatt
Mar 15, 2015·American Journal of Epidemiology·Tram Kim LamSheri D Schully
Jan 27, 2017·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Julie A LynchJohn Kautter
May 10, 2017·Journal of Clinical and Translational Science·Daniel G FortJustin B Starren
Nov 27, 2019·History and Philosophy of the Life Sciences·Anne K KruegerStephan Gauch
Apr 15, 2020·Addiction Biology·Lara A RayGeorge F Koob

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