Evolution of the functional profile of HIV-specific CD8+ T cells in patients with different progression of HIV infection over 4 years

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Alejandra Peris-PertusaJosé Miguel Benito

Abstract

There is a lack of information about the stability of these responses over time in subjects experiencing differences in HIV disease progression. The functional profile of Gag-specific and Nef-specific CD8T-cell responses based on the simultaneous production macrophage inflammatory protein (MIP)-1beta, interleukin (IL)-2, and tumor necrosis factor (TNF)-alpha was longitudinally assessed using flow cytometry over 4 years in 8 elite controllers (EC), 8 viremic controllers, 10 antiretroviral-naive typical progressors, and 10 patients with virological suppression (VS) on antiretroviral therapy. CD8 T-cell subsets with 2 functions tended to decline, whereas subsets with 1 function tended to increase over time in typical progressors. In viremic controller, Gag and Nef responses evolved differently. In EC, the functional profile of Gag-specific CD8T-cell responses evolved increasing polyfunctionality over time. Finally, Nef-specific responses in VS increased in the MIP+TNF-IL2- CD8 T-cell subset while Gag-specific responses did not change. The functional profile of HIV-specific CD8T-cell responses may evolve in different ways depending of the targeted HIV protein and the ability to control virus replication. In patients with uncontroll...Continue Reading

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Citations

Apr 25, 2012·Journal of Neurovirology·Lauren A Wendelken, Victor Valcour
Jan 27, 2012·Journal of Virology·Sara Ferrando-MartínezEzequiel Ruiz-Mateos
May 14, 2016·PloS One·Lander Egaña-GorroñoUNKNOWN HIV Controllers Consortium of the AIDS Spanish Network
Apr 6, 2017·PloS One·Fanny ChereauUNKNOWN HIV Controllers Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in
Mar 20, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lea BrandtIngrid Karlsson
Aug 16, 2019·JCI Insight·Stephen A MiguelesJoseph A Kovacs
Jul 22, 2018·F1000Research·Sushma Boppana, Paul Goepfert

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