Evolution of the IS6110-based restriction fragment length polymorphism pattern during the transmission of Mycobacterium tuberculosis.

Journal of Clinical Microbiology
R M WarrenP D Van Helden

Abstract

Interpretation of the molecular epidemiological data of Mycobacterium tuberculosis is dependent on the validity of the assumptions that have been made. It is assumed that the IS6110 banding pattern is sufficiently stable to define epidemiological events representing ongoing transmission. However, molecular epidemiological data also support the observation that the IS6110 banding pattern may change over time. Factors affecting this rate may include the nature and duration of disease in a host and the opportunity to experience different host environments during the transmission cycle. To estimate the rate of IS6110 change occurring during the process of transmission, M. tuberculosis isolates from epidemiologically linked patients were genotypically characterized by restriction fragment length polymorphism (RFLP) analysis. The identification of IS6110 banding pattern changes during ongoing transmission suggested that a rate could be estimated. IS6110 change was significantly associated with strains with >5 IS6110 elements (P = 0.013) and was not observed in low-copy-number isolates. The minimum rate of appearance of variant strains was calculated to be 0.14 variant cases per source-case per year. This data suggest that clustering ...Continue Reading

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Citations

Sep 24, 2011·Journal of Clinical Microbiology·Laura Pérez-LagoDarío García de Viedma
Oct 12, 2007·Journal of Clinical Microbiology·Riza DurmazNalin Rastogi
Jul 11, 2006·Journal of Clinical Microbiology·Krishna K GopaulFrancis A Drobniewski
Dec 10, 2003·Journal of Clinical Microbiology·G D van der SpuyP D van Helden
Dec 8, 2004·Journal of Clinical Microbiology·Isdore Chola ShamputaFrançoise Portaels
Mar 9, 2004·Journal of Clinical Microbiology·Madalene RichardsonRobin M Warren
Jun 9, 2004·Journal of Clinical Microbiology·Paul H C EilersMartien W Borgdorff
Jan 1, 2004·American Journal of Respiratory and Critical Care Medicine·Robin M WarrenPaul D van Helden
Sep 23, 2003·American Journal of Respiratory and Critical Care Medicine·Dao NguyenMarcel A Behr
Mar 4, 2011·Future Microbiology·Midori Kato-MaedaLaura Flores
May 18, 2006·Emerging Infectious Diseases·Amelia C CrampinPaul E M Fine
Mar 22, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Florian M MarxNulda Beyers
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Feb 7, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L Pérez-LagoD García-de-Viedma
Oct 30, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chih-Yun YangRuay-Ming Huang
Feb 22, 2012·Tuberculosis·Laura Pérez-LagoDarío García de Viedma
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Jan 1, 2013·The Annals of Applied Statistics·Charles R DossVladimir N Minin

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